Immunoglobulin A - Research News and Information

Saturday, January 10, 2009

Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

14 Oct 2008 Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth ... Read more...

Cholera toxin-specific memory B cell responses are induced in patients with dehydrating diarrhea caused by Vibrio cholerae O1.

29 Sep 2008 BACKGROUND: Infection with Vibrio cholerae induces durable immunity against subsequent disease, a process hypothesized to reflect anamnestic immune responses at the intestinal mucosa. The presence of antigen-specific memory B cells may therefore be ... Read more...

Characterization of monoclonal immunoglobulin a and g against shiga toxin binding subunits produced by intranasal immunization.

29 Sep 2008 Immunoglobulin A (IgA) is considered to play a major role in protection of the mucosal surface. However, its immunological and biological properties have not been extensively studied because the production of IgA class monoclonal antibodies (mAbs) ... Read more...

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Latest indexed articles for 'Immunoglobulin A'

These are the very latest articles for this heading:

• Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection. 14 Oct 2008
• Cholera toxin-specific memory B cell responses are induced in patients with dehydrating diarrhea caused by Vibrio cholerae O1. 29 Sep 2008
• Characterization of monoclonal immunoglobulin a and g against shiga toxin binding subunits produced by intranasal immunization. 29 Sep 2008
• The beneficial effect of oral calcitriol treatment on proteinuria in IgA nephropathy: another point of view. 29 Sep 2008
• Analysis of IgA1 N-glycosylation and its contribution to FcalphaRI binding. 29 Sep 2008
• "Give us this day our daily bread"--evolving concepts in celiac sprue. 29 Sep 2008
• A potential role for B-cell activating factor in the pathogenesis of autoimmune myasthenia gravis. 29 Sep 2008
• A readily available assay for anti-immunoglobulin A: is this what we have been waiting for? 29 Sep 2008
• [Nasal vaccines] 29 Sep 2008
• Pattern of humoral immune response to Plasmodium falciparum blood stages in individuals presenting different clinical expressions of malaria. 22 Sep 2008
• Mucosal administration of completely non-replicative vaccinia virus recombinant Dairen I strain elicits effective mucosal and systemic immunity. 16 Sep 2008
• Effect of neonatal sublingual vaccination with native or denatured ovalbumin and adjuvant CpG or cholera toxin on systemic and mucosal immunity in mice. 10 Sep 2008
• Characterization of rotavirus specific B cells and their relation with serological memory. 9 Sep 2008
• Protective immunity against influenza H5N1 virus challenge in mice by intranasal co-administration of baculovirus surface-displayed HA and recombinant CTB as an adjuvant. 8 Sep 2008
• An alphavirus replicon-based human metapneumovirus vaccine is immunogenic and protective in mice and cotton rats. 8 Sep 2008
• The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients. 6 Sep 2008
• Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach. Sep 2008
• IgA deposits along glomerular basement membranes in rapidly progressive glomerulonephritis. 30 Aug 2008
• Heparin-induced antibodies and cardiovascular risk in patients on dialysis. 30 Aug 2008
• [Antibody response after immunization with a Salmonella Typhimurium live vaccine in dependence on the way of application] 30 Aug 2008

See a longer list of these articles.

Technical information about 'Immunoglobulin A'

Definition: Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.

Registry Number: 0

Descriptor UI: D007070

Alternative terms: Immunoglobulin A; IgA; IgA1; IgA2;

Related Mesh Headings: Immunoglobulin J-Chains;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacology; physiology; poisoning; radiation effects; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Pharmacological Action: Immunologic Factors;

Tree Number: D12.776.124.486.485.114.619.026; D12.776.124.790.651.114.619.026; D12.776.377.715.548.114.619.026;

History Note: 2002(1971)

Technical Notes: gammopathy: coordinate IMMUNOGLOBULIN A (IM) with PARAPROTEINEMIAS (IM) but consider also HYPERGAMMAGLOBULINEMIA (IM), follow text; salivary immunoglobulin A: index IGA, SECRETORY + SALIVA/ immunol; immunoglobulin A in tears: index IGA, SECRETORY + TEARS/ immunol