Immunoglobulin Fragments - Research News and Information

Saturday, January 10, 2009

Differential presentation of tumor antigen-derived epitopes by MHC-class I and antigen-positive tumor cells.

13 Oct 2008 SSX2 is a member of the family of cancer/testis antigens. The SSX2 derived peptide SSX2(103-111) has been shown to be presented to cytotoxic T-lymphocytes (CTL) by Major-Histocompatibility (MHC) Class-I complexes after endogenous processing, more ... Read more...

Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.

23 Sep 2008 A single-domain fragment, cAb-HuL22, of a camelid heavy-chain antibody specific for the active site of human lysozyme has been generated, and its effects on the properties of the I56T and D67H amyloidogenic variants of human lysozyme, which are ... Read more...

Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from Yeast.

8 Sep 2008 BACKGROUND: The ability of cytosine deaminase (CD) to convert the antifungal agent 5-fluorocytosine (5-FC) into one of the most potent and largely used anticancer compound such as 5-fluorouracil (5-FU) raised considerable interest in this enzyme to ... Read more...

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Latest indexed articles for 'Immunoglobulin Fragments'

These are the very latest articles for this heading:

• Differential presentation of tumor antigen-derived epitopes by MHC-class I and antigen-positive tumor cells. 13 Oct 2008
• Comment on "Production of multivalent protein binders using a self-trimerization collagen-like peptide scaffold". 29 Sep 2008
• Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils. 23 Sep 2008
• Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from Yeast. 8 Sep 2008
• Development of human antibody fragments using antibody phage display for the detection and diagnosis of Venezuelan equine encephalitis virus (VEEV). 31 Aug 2008
• Multivalency: the hallmark of antibodies used for optimization of tumor targeting by design. 30 Aug 2008
• Specific targeting of hepatitis C virus core protein by an intracellular single-chain antibody of human origin. 30 Aug 2008
• T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. 5 Aug 2008
• A novel bivalent single-chain variable fragment (scFV) inhibits the action of tumour necrosis factor alpha. 30 Jul 2008
• Human scFv SIgA expressed on Lactococcus lactis as a vector for the treatment of mucosal disease. 30 Jul 2008
• Persistent monoclonality after histological remission in gastric mucosa-associated lymphoid tissue lymphoma treated with chemotherapy and/or surgery: influence of t(11;18)(q21;q21). 30 Jul 2008
• Llama-derived single-chain antibody fragments directed to rotavirus VP6 protein possess broad neutralizing activity in vitro and confer protection against diarrhea in mice. 14 Jul 2008
• Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus. 14 Jul 2008
• Cloning, expression, and characterization of a single-domain antibody fragment with affinity for 15-acetyl-deoxynivalenol. 13 Jul 2008
• Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease. 30 Jun 2008
• Force-based analysis of multidimensional energy landscapes: application of dynamic force spectroscopy and steered molecular dynamics simulations to an antibody fragment-peptide complex. 26 Jun 2008
• A double epitope tag for quantification of recombinant protein using fluorescence resonance energy transfer. Jun 2008
• Crystal structure of single-domain VL of an anti-DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals. 30 May 2008
• Immobilization strategies for single-chain antibody microarrays. 30 May 2008
• Detection of pancreatic cancer using antibody microarray-based serum protein profiling. 30 May 2008

See a longer list of these articles.

Technical information about 'Immunoglobulin Fragments'

Definition: Partial immunoglobulin molecules resulting from selective cleavage by proteolytic enzymes or generated through PROTEIN ENGINEERING techniques.

Registry Number: 0

Descriptor UI: D007128

Alternative terms: Immunoglobulin Fragments; Fragments, Immunoglobulin; Antibody Fragments;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacology; physiology; poisoning; radiation effects; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Pharmacological Action: Immunologic Factors;

Tree Number: D12.776.124.486.485.680; D12.776.124.790.651.680; D12.776.377.715.548.680;

History Note: 73

Technical Notes: DF: IG FRAGMENTS