Immunoglobulin G - Metabolism
Research News and Information

Friday, March 19, 2010

Branch-specific sialylation of IgG-Fc glycans by ST6Gal-I.

18 Oct 2009 Sialylated forms of the Fc fragment of immunoglobulin G, produced by the human alpha2-6 sialyltransferase ST6Gal-I, were identified as potent anti-inflammatory mediators in a mouse model of rheumatoid arthritis and are potentially the active ... Read more...

Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies.

29 Sep 2009 Neuromyelitis optica (NMO) is an inflammatory autoimmune demyelinating disease of the central nervous system (CNS) which in autoantibodies produced by patients with NMO (NMO-IgG) recognize a glial water channel protein, Aquaporin-4 (AQP4) expressed ... Read more...

Transient neonatal acquired von Willebrand syndrome due to transplacental transfer of maternal monoclonal antibodies.

29 Sep 2009 Although typically a disorder of adults, acquired von Willebrand syndrome (AVWS) is increasingly being recognized in the pediatric population in association with congenital cardiac diseases, certain neoplasia, and hypothyroidism. Transplacental ... Read more...

Latest indexed articles for 'Immunoglobulin G - Metabolism'

These are the very latest articles for this heading:

• Etanercept during pregnancy and lactation in a patient with rheumatoid arthritis: drug levels in maternal serum, cord blood, breast milk and the infant's serum. 30 Oct 2009
• Branch-specific sialylation of IgG-Fc glycans by ST6Gal-I. 18 Oct 2009
• Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies. 29 Sep 2009
• Transient neonatal acquired von Willebrand syndrome due to transplacental transfer of maternal monoclonal antibodies. 29 Sep 2009
• CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. 2 Sep 2009
• IgG4-related interstitial lung disease: a new and evolving concept. 30 Aug 2009
• Detection and quantitation of IgG 1 hinge aspartate isomerization: a rapid degradation in stressed stability studies. 30 Aug 2009
• Sugar-free antibodies--the bacterial solution to autoimmunity? 30 Aug 2009
• Characterization of the photodegradation of a human IgG1 monoclonal antibody formulated as a high-concentration liquid dosage form. 30 Aug 2009
• Two novel IgG endopeptidases of Streptococcus equi. 30 Aug 2009
• Studies on the mechanism by which antigen-specific IgG suppresses primary antibody responses: evidence for epitope masking and decreased localization of antigen in the spleen. 30 Aug 2009
• Integrated fragmentation of human IgG and purification of Fab using a reactant adsorptive membrane bioreactor separator system. 30 Aug 2009
• A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis. 29 Aug 2009
• eNOS gene deletion restores blood-brain barrier integrity and attenuates neurodegeneration in the thiamine-deficient mouse brain. 15 Aug 2009
• Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia. 13 Aug 2009
• Modulation of single-cell IgG secretion frequency and rates in human memory B cells by CpG DNA, CD40L, IL-21, and cell division. 10 Aug 2009
• Sclerosing angiomatoid nodular transformation (SANT) of the spleen: a report of 3 cases. 8 Aug 2009
• FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. 3 Aug 2009
• An interspecies comparison of placental antibody transfer: new insights into developmental toxicity testing of monoclonal antibodies. 30 Jul 2009
• Redox-reactive autoantibodies: biochemistry, characterization, and specificities. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Immunoglobulin G'

Definition: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Registry Number: 0

Descriptor UI: D007074

Alternative terms: Immunoglobulin G; Gamma Globulin, 7S; 7S Gamma Globulin; IgG; IgG2A; IgG2B; Polyglobin; Allerglobuline; IgG(T); Immunoglobulin GT; GT, Immunoglobulin; IgG1; IgG4; IgG2; IgG3;

Related Mesh Headings: Receptors, IgG;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacology; physiology; poisoning; radiation effects; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Pharmacological Action: Immunologic Factors;

Tree Number: D12.776.124.486.485.114.619.393; D12.776.124.790.651.114.619.393; D12.776.377.715.548.114.619.393;

History Note: 2002(1971)

Technical Notes: gammopathy: coordinate IMMUNOGLOBULIN G (IM) with PARAPROTEINEMIAS (IM) but consider also HYPERGAMMAGLOBULINEMIA, follow text