Immunoglobulin Heavy Chains - Research News and Information

Saturday, January 10, 2009

BCL2 and BCL3 are recurrent translocation partners of the IGH locus.

13 Oct 2008 Chromosomal translocations affecting the immunoglobulin heavy chain (IGH) locus in chromosomal band 14q32 are the most frequent cytogenetic changes in B-cell lymphomas. We studied the presence of IGH translocations in a consecutively ascertained ... Read more...

Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients.

28 Sep 2008 BACKGROUND: The impact of meningeal dissemination in primary CNS lymphoma (PCNSL) is debated, and the reported frequency varies. We prospectively evaluated the diagnostic value of PCR in comparison with CSF cytomorphology and MRI for diagnosing ... Read more...

Multiple levels of selection responsive to immunoglobulin light chain and heavy chain structures impede the development of Dmu-expressing B cells.

13 Sep 2008 The truncated/V(H)-less mouse H chain Dmu forms precursor B cell receptors with the surrogate L chain complex that promotes allelic exclusion but not other aspects of pre-B cell development, causing most progenitor B cells expressing this H chain ... Read more...

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Latest indexed articles for 'Immunoglobulin Heavy Chains'

These are the very latest articles for this heading:

• BCL2 and BCL3 are recurrent translocation partners of the IGH locus. 13 Oct 2008
• Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients. 28 Sep 2008
• Multiple levels of selection responsive to immunoglobulin light chain and heavy chain structures impede the development of Dmu-expressing B cells. 13 Sep 2008
• Impact of a three amino acid deletion in the CH2 domain of murine IgG1 on Fc-associated effector functions. 13 Sep 2008
• A new gibberellin detection system in living cells based on antibody V(H)/V(L) interaction. 3 Sep 2008
• Regulating antibody diversity: taming a mutagen. 3 Sep 2008
• Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia. 30 Aug 2008
• A unique role for the lambda5 nonimmunoglobulin tail in early B lymphocyte development. 30 Aug 2008
• Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen. 30 Aug 2008
• [Case of metachronous mucosa-associated lymphoid tissue (MALT) lymphoma originated from a distinct B-cell clone] 30 Aug 2008
• Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing. 20 Aug 2008
• C-terminal lysine variants in fully human monoclonal antibodies: investigation of test methods and possible causes. 13 Aug 2008
• Selective recognition of a DNA G-quadruplex by an engineered antibody. 13 Aug 2008
• Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. 5 Aug 2008
• Monoclonal B-cell lymphocytosis--a frequent premalignant condition. 5 Aug 2008
• Malleable immunoglobulin genes and hematopathology - the good, the bad, and the ugly: a paper from the 2007 William Beaumont hospital symposium on molecular pathology. 5 Aug 2008
• Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes. 30 Jul 2008
• Anaplastic large cell lymphoma associated with a breast implant capsule: a case report and review of the literature. 30 Jul 2008
• Successful use of semi-nested PCR for the diagnosis of primary intraocular lymphoma. 30 Jul 2008
• The spectrum of B-cell non-Hodgkin lymphomas with dual IgH-BCL2 and BCL6 translocations. 30 Jul 2008

See a longer list of these articles.

Technical information about 'Immunoglobulin Heavy Chains'

Definition: The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.

Registry Number: 0

Descriptor UI: D007143

Alternative terms: Immunoglobulin Heavy Chains; Heavy Chains, Immunoglobulin; Ig Heavy Chains; Heavy Chains, Ig; Immunoglobulins, Heavy-Chain; Immunoglobulins, Heavy Chain; Heavy-Chain Immunoglobulins; Heavy Chain Immunoglobulins; Immunoglobulin Heavy Chain; Heavy Chain, Immunoglobulin; Immunoglobulin Heavy Chain Subgroup VH-I; Immunoglobulin Heavy Chain Subgroup VH I; Immunoglobulin Heavy Chain Subgroup VH-III; Immunoglobulin Heavy Chain Subgroup VH III;

Related Mesh Headings: Heavy Chain Disease;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacology; physiology; poisoning; radiation effects; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Pharmacological Action: Immunologic Factors;

Tree Number: D12.776.124.486.485.705.500; D12.776.124.790.651.705.500; D12.776.377.715.548.705.500;

History Note: 2006 (1973)

Technical Notes: gammopathy: coordinate IMMUNOGLOBULIN HEAVY CHAINS (IM) with PARAPROTEINEMIAS (IM) but consider also HYPERGAMMAGLOBULINEMIA (IM) or HEAVY CHAIN DISEASE (IM), follow text; DF: IG HEAVY CHAIN