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In Situ Nick-End Labeling
Research News and Information
Definition of 'In Situ Nick-End Labeling'An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION. |
Monday, November 23, 2009
Minocycline inhibition of photoreceptor degeneration.
30 Oct 2009 
OBJECTIVE: To determine whether systemic minocycline can protect photoreceptors in experimental retinal detachment (RD). METHODS: Retinal detachment was induced in mice by subretinal injection of sodium hyaluronate, 1.4%. In 1 experiment, mice ... Read more...
30 Oct 2009 OBJECT: Apoptosis is implicated in vasospasm and long-term sequelae of subarachnoid hemorrhage (SAH). The authors observed that 17beta-estradiol (E2) can attenuate cerebral vasospasm, lower endothelin-1 production, and preserve normal endothelial ... Read more...
Oxidative stress disrupts oligodendrocyte maturation.
30 Oct 2009 Periventricular white matter injury (PWMI) is the leading cause of chronic neurologic injury among survivors of preterm birth. The hallmark of PWMI is hypomyelination and a lack of mature, myelinating oligodendrocytes. Oligodendrocytes undergo a ... Read more...
Latest indexed articles for 'In Situ Nick-End Labeling'
These are the very latest articles for this heading:
- Minocycline inhibition of photoreceptor degeneration. 30 Oct 2009
- Attenuation of subarachnoid hemorrhage-induced apoptotic cell death with 17 beta-estradiol. Laboratory investigation. 30 Oct 2009
- Oxidative stress disrupts oligodendrocyte maturation. 30 Oct 2009
- Contribution of Kv channel subunits to glutamate-induced apoptosis in cultured rat hippocampal neurons. 30 Oct 2009
- Quantification of radiation-induced single-strand breaks in plasmid DNA using a TUNEL/ELISA-based assay. 30 Oct 2009
- Interaction of B7-H1 on intrahepatic cholangiocarcinoma cells with PD-1 on tumor-infiltrating T cells as a mechanism of immune evasion. 30 Oct 2009
- Comparison of ACINUS, caspase-3, and TUNEL as apoptotic markers in determination of tumor growth rates of clinically localized prostate cancer using image analysis. 30 Oct 2009
- Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. 30 Oct 2009
- Apoptosis in patients with acute myocarditis. 29 Sep 2009
- X-radiation induces non-small-cell lung cancer apoptosis by upregulation of Axin expression. 29 Sep 2009
- Usefulness of HIF-1 imaging for determining optimal timing of combining bevacizumab and radiotherapy. 29 Sep 2009
- Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. 25 Sep 2009
- Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. 22 Sep 2009
- E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases. 15 Sep 2009
- Ocular abnormalities in mice lacking the immunoglobulin superfamily member Cdo. 13 Sep 2009
- Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia. 7 Sep 2009
- An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. 4 Sep 2009
- EFHC1 interacts with microtubules to regulate cell division and cortical development. 4 Sep 2009
- Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. 4 Sep 2009
- Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation. 31 Aug 2009
See a longer list of these articles.
Technical information about 'In Situ Nick-End Labeling'
Definition: An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
Descriptor UI: D020287
Alternative terms: In Situ Nick-End Labeling; TUNEL; Nick-End Labeling, In Situ; In Situ Nick End Labelling; In Situ Nick End Labeling; In Situ Nick End-Labelling; In Situ Nick-End Labelling; Nick End-Labeling, In Situ; Nick End Labeling, In Situ; Nick End-Labelling, In Situ; Nick End Labelling, In Situ; Nick-End Labelling, In Situ; In Situ Nick End-Labeling;
Related Mesh Headings: Apoptosis; Comet Assay;
Allowable Qualifiers: classification; economics; history; instrumentation; methods; standards; trends; utilization; veterinary; statistics & numerical data; ethics;
Tree Number: E05.393.475;
History Note: 99