Indans - Pharmacology
Research News and Information

Monday, November 23, 2009

Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium.

4 Aug 2009 Our recent studies have shown that, as indicated by vagal stimulation, an acetylcholinesterase inhibitor donepezil, an anti-Alzheimer's disease drug, prevents progression of heart failure in rats with myocardial infarction, and activates a common ... Read more...

Acute cognitive effects of donepezil in young, healthy volunteers.

30 Jul 2009 OBJECTIVE: The acute nootropic potential of donepezil in young healthy volunteers has not been adequately investigated mainly because in previous studies: (1) effects were assessed before peak-plasma concentration (Tmax) was reached; (2) only a few ... Read more...

The inhibitory avoidance test optimized for discovery of cognitive enhancers.

30 Jul 2009 In the present article, we describe a new protocol for the inhibitory avoidance test, with a dual purpose: (1) to provide a less variable and more reliable assessment of the efficacy of potential cognitive enhancers in antagonizing ... Read more...

Latest indexed articles for 'Indans - Pharmacology'

These are the very latest articles for this heading:

• Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium. 4 Aug 2009
• Acute cognitive effects of donepezil in young, healthy volunteers. 30 Jul 2009
• The inhibitory avoidance test optimized for discovery of cognitive enhancers. 30 Jul 2009
• The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome. 30 Jul 2009
• Donepezil improves episodic memory in young individuals vulnerable to the effects of sleep deprivation. 30 Jul 2009
• The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain. 12 Jul 2009
• Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma. 5 Jul 2009
• Isoform-specific inhibition of cyclophilins. 5 Jul 2009
• Recovery of cognitive dysfunction in a case of delayed encephalopathy of carbon monoxide poisoning after treatment with donepezil hydrochloride. 29 Jun 2009
• DHPG activation of group 1 mGluRs in BLA enhances fear conditioning. 22 Jun 2009
• Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. 15 Jun 2009
• Regulatory role of tyrosine phosphorylation in the swelling-activated chloride current in isolated rabbit articular chondrocytes. 13 Jun 2009
• Clinical effects of high oral dose of donepezil for patients with Alzheimer's disease in Japan. 30 May 2009
• Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent subchronic administration of donepezil: role of sigma-1 receptors. 7 May 2009
• Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives. 3 May 2009
• PPAR gamma partial agonist, KR-62776, inhibits adipocyte differentiation via activation of ERK. 29 Apr 2009
• Donepezil in the treatment of patients with Alzheimer's disease. 29 Apr 2009
• D3 dopamine receptor regulation of ETB receptors in renal proximal tubule cells from WKY and SHRs. 21 Apr 2009
• In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment. 5 Apr 2009
• JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. 31 Mar 2009

See a longer list of these articles.

Technical information about 'Indans'

Definition: Aryl CYCLOPENTANES that are a reduced (protonated) form of INDENES.

Registry Number: 0

Descriptor UI: D007189

Alternative terms: Indans; Indanones;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.426.559.847.486.487; D04.615.486.487;

Online Note: search INDENES 1966-74

History Note: 91(75)63-67; was see under INDENES 1975-90; was heading 1963-67