Indoprofen - Research News and Information

Saturday, January 10, 2009

Dexibuprofen (S(+)-isomer ibuprofen) reduces microglial activation and impairments of spatial working memory induced by chronic lipopolysaccharide infusion.

31 Jan 2008 Non-steroidal anti-inflammatory drugs (NSAIDs) have been proposed as a therapeutics to reduce the risk of Alzheimer's disease (AD). The present study shows that the peripheral administration of dexibuprofen (S(+)-isomer ibuprofen), which causes ... Read more...

Isoindol-1,3-dione and isoindol-1-one derivatives with high binding affinity to beta-amyloid fibrils.

17 Jan 2008 Based on the structural features of Indoprofen and PIB, a series of isoindol-1,3-diones 1a-k and isoindol-1-ones 2a-l were designed and synthesized. These 23 compounds were evaluated by competitive binding assay against aggregated Abeta42 fibrils ... Read more...

A randomized, crossover study to determine bioequivalence of two brands of dexibuprofen 400 mg tablets in healthy Asian adult male subjects of Indian origin.

30 Dec 2007 AIM: To estimate the bioavailability and evaluate bioequivalence of a single dose of a dexibuprofen tablet (test formulation, containing dexibuprofen 400 mg, manufactured by Emcure Pharmaceuticals Ltd., Pune, India) and to compare it with that of a ... Read more...

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Latest indexed articles for 'Indoprofen'

These are the very latest articles for this heading:

• Dexibuprofen (S(+)-isomer ibuprofen) reduces microglial activation and impairments of spatial working memory induced by chronic lipopolysaccharide infusion. 31 Jan 2008
• Isoindol-1,3-dione and isoindol-1-one derivatives with high binding affinity to beta-amyloid fibrils. 17 Jan 2008
• A randomized, crossover study to determine bioequivalence of two brands of dexibuprofen 400 mg tablets in healthy Asian adult male subjects of Indian origin. 30 Dec 2007
• Modification of pepsinogen I levels and their correlation with gastrointestinal injury after administration of dexibuprofen, ibuprofen or diclofenac: a randomized, open-label, controlled clinical trial. 30 Mar 2006
• The effect of a dexibuprofen mouth rinse on experimental gingivitis in humans. 30 May 2005
• Comparative study of the photophysical properties of indoprofen photoproducts in relation with their DNA photosensitizing properties. 18 Jan 2005
• Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism. 30 Oct 2004
• DNA photosensitization by indoprofen - is DNA damage photoinduced by indoprofen or by its photoproducts? 18 Nov 2003
• Photochemical and photophysical properties of indoprofen. 29 Apr 2003
• A three-component coupling process based on vicarious nucleophilic substitution (VNS(AR))-alkylation reactions: an approach to indoprofen and derivatives. 23 Jan 2002
• Aseptic meningo-encephalitis related to dexibuprofen use in a patient with systemic lupus erythematosus: a case report with MR findings. 30 Dec 2001
• Computer simulation of the interaction of non-steroidal anti-inflammatory drugs: indoprofen and NS398 with cyclooxygenase. 30 Jan 1999
• Evidence for a multidrug resistance-associated protein 1 (MRP1)-related transport system in cultured rat liver biliary epithelial cells. 30 Dec 1998
• Effect of some cyclooxygenase inhibitors on the increase in guanosine 3':5'-cyclic monophosphate induced by NO-donors in human whole platelets. 30 Mar 1998
• Non-steroidal anti-inflammatory drugs. III. Structure of indoprofen: 2-[4-(1-oxo-2-isoindolinyl)phenyl]propionic acid. 13 Apr 1994
• The in vitro metabolic inversion of R(-) to S(+) indoprofen. 29 Jun 1992
• Mechanism of allergic cross-reactions--I. Multispecific binding of ligands to a mouse monoclonal anti-DNP IgE antibody. 30 May 1991
• [Binding of racemic indoprofen and its enantiomers to human serum albumin] 30 May 1989
• [Indoprofen in chronic intermittent peritoneal dialysis: effects in the clearance of small molecules and protein loss] 29 Apr 1989
• Evidence of a central component in the analgesic effect of indoprofene. 30 Dec 1988

See a longer list of these articles.

Technical information about 'Indoprofen'

Definition: A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21)

Chemical name: Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-alpha-methyl-

Registry Number: 31842-01-0

Descriptor UI: D007216

Alternative terms: Indoprofen; Dexindoprofen;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Cyclooxygenase Inhibitors;

Tree Number: D02.241.223.701.450; D03.438.513.374;

History Note: 91(79); was see under PHENYLPROPIONATES 1979-90