Inositol - Research News and Information

Saturday, January 10, 2009

Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain.

30 Aug 2008 Ablation of the murine Slc5a3 gene results in severe myo-inositol (Ins) deficiency and congenital central apnea due to abnormal respiratory rhythmogenesis. The lethal knockout phenotype may be rescued by supplementing the maternal drinking water ... Read more...

Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria.

30 Aug 2008 Mycothiol (MSH; AcCys-GlcN-Ins) is the major thiol found in Actinobacteria and has many of the functions of glutathione, which is the dominant thiol in other bacteria and eukaryotes but is absent in Actinobacteria. MSH functions as a protected ... Read more...

Intramolecular direct aldol reactions of sugar diketones: syntheses of valiolamine and validoxylamine G.

24 Aug 2008 A new and stereoselective intramolecular direct aldol reaction of diketones derived from carbohydrates has been developed to construct carbocycles with D-gluco-, D-galacto-, D-manno-, and L-ido-configurations. The stereochemical outcome of the ... Read more...

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Latest indexed articles for 'Inositol'

These are the very latest articles for this heading:

• Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain. 30 Aug 2008
• Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria. 30 Aug 2008
• Intramolecular direct aldol reactions of sugar diketones: syntheses of valiolamine and validoxylamine G. 24 Aug 2008
• Two divergent genes encoding L-myo-inositol 1-phosphate synthase1 (CaMIPS1) and 2 (CaMIPS2) are differentially expressed in chickpea. 17 Aug 2008
• Disruption of the SCS2 ortholog in the alkane-assimilating yeast Yarrowia lipolytica impairs its growth on n-decane, but does not impair inositol prototrophy. 5 Aug 2008
• 1H MRS identifies symptomatic and asymptomatic subjects with partial ornithine transcarbamylase deficiency. 24 Jul 2008
• Transcriptional and metabolic profiling of grape (Vitis vinifera L.) leaves unravel possible innate resistance against pathogenic fungi. 20 Jul 2008
• Risk for metabolic syndrome predisposes to alterations in the thalamic metabolism. 20 Jul 2008
• Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis. 19 Jul 2008
• The effect of dietary supplementation with limonene or myo-inositol on the induction of neoplasia and matrix metalloproteinase and plasminogen activator activities in accessory sex organs of male Lobund-Wistar rats. 15 Jul 2008
• An N-acyl homolog of mycothiol is produced in marine actinomycetes. 14 Jul 2008
• Huntington's disease: degradation of mutant huntingtin by autophagy. 13 Jul 2008
• Inositol methyl tranferase from a halophytic wild rice, Porteresia coarctata Roxb. (Tateoka): regulation of pinitol synthesis under abiotic stress. 12 Jul 2008
• Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease. 9 Jul 2008
• Protective effect of pinitol against D-galactosamine-induced hepatotoxicity in rats fed on a high-fat diet. 5 Jul 2008
• Small molecule enhancers of autophagy for neurodegenerative diseases. 2 Jul 2008
• Structural, functional and calorimetric investigation of MosA, a dihydrodipicolinate synthase from Sinorhizobium meliloti l5-30, does not support involvement in rhizopine biosynthesis. 30 Jun 2008
• Inositol supplementation in pregnancies at risk of apparently folate-resistant NTDs. 29 Jun 2008
• Comments on inositol supplementation in pregnancies at risk of apparently folate-resistant NTDs. 29 Jun 2008
• Identification and quantitative analysis of stage-specific carbohydrates in loblolly pine (Pinus taeda) zygotic embryo and female gametophyte tissues. 29 Jun 2008

See a longer list of these articles.

Technical information about 'Inositol'

Definition: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.

Registry Number: 6917-35-7

Descriptor UI: D007294

Alternative terms: Inositol; Myoinositol; Chiro-Inositol; Chiro Inositol; Mesoinositol;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Vitamin B Complex;

Tree Number: D02.033.800.519; D09.853.519;