Insulin - Pharmacology
Research News and Information

Monday, November 23, 2009

Kinetics of transport and phosphorylation of glucose in cancer cells.

29 Nov 2009 Metabolic control analysis of tumor glycolysis has indicated that hexokinase (HK) and glucose transporter (GLUT) exert the main flux control (71%). To understand why they are the main controlling steps, the GLUT and HK kinetics and the contents of ... Read more...

Rapamycin impairs trabecular bone acquisition from high-dose but not low-dose intermittent parathyroid hormone treatment.

29 Nov 2009 The osteo-anabolic effects of intermittent parathyroid hormone (PTH) treatment require insulin-like growth factor (IGF) signaling through the IGF-I receptor. A major downstream target of the IGF-I receptor (via Akt) is the mammalian target of ... Read more...

Effect of adipose tissue on the sexual dimorphism in metabolic flexibility.

30 Oct 2009 Metabolic flexibility is the ability to transition between fat oxidation (fasting state) and glucose oxidation (fed state). We hypothesized that adipose tissue inflammation and lipid metabolism contribute to sexual dimorphism in metabolic ... Read more...

Latest indexed articles for 'Insulin - Pharmacology'

These are the very latest articles for this heading:

• Kinetics of transport and phosphorylation of glucose in cancer cells. 29 Nov 2009
• Rapamycin impairs trabecular bone acquisition from high-dose but not low-dose intermittent parathyroid hormone treatment. 29 Nov 2009
• Effect of adipose tissue on the sexual dimorphism in metabolic flexibility. 30 Oct 2009
• Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart. 10 Oct 2009
• Comparison of preservation solutions in an experimental model of organ cooling in kidney transplantation. 29 Sep 2009
• Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. 6 Sep 2009
• Stealth nanoparticles coated with heparin as peptide or protein carriers. 30 Aug 2009
• Therapy: Intensive glucose control in the ICU: is sugar nice? 30 Aug 2009
• Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function. 30 Aug 2009
• Potential dysregulation of the pyruvate dehydrogenase complex by bacterial toxins and insulin. 30 Aug 2009
• Effect of insulin on airway responsiveness in patients with type 2 diabetes mellitus: a cohort study. 30 Aug 2009
• Functional analysis of the -2548G/A leptin gene polymorphism in breast cancer cells. 30 Aug 2009
• Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. 29 Aug 2009
• Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways. 21 Aug 2009
• Implication of activin E in glucose metabolism: transcriptional regulation of the inhibin/activin betaE subunit gene in the liver. 20 Aug 2009
• Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells. 13 Aug 2009
• Developmentally spliced PKCbetaII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport. 13 Aug 2009
• Transcriptional regulation of mitochondrial glycerophosphate acyltransferase is mediated by distal promoter via ChREBP and SREBP-1. 11 Aug 2009
• ENPP1 Q121 variant, increased pulse pressure and reduced insulin signaling, and nitric oxide synthase activity in endothelial cells. 11 Aug 2009
• GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation. 11 Aug 2009

See a longer list of these articles.

Technical information about 'Insulin'

Definition: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

Chemical name: Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-

Registry Number: 11061-68-0

Descriptor UI: D007328

Alternative terms: Insulin; Insulin, Regular; Regular Insulin; Humulin S; Iletin; Insulin A Chain; Insulin, Globin Zinc; Globin Zinc Insulin; Velosulin; Insulin, Regular, Human; Insulin, Regular, Pork; Novolin; Sodium Insulin; Insulin, Sodium; Type I Insulin; Insulin, Type I; Type II Insulin; Insulin, Type II; Humulin; Insulin, Regular, Beef-Pork;

Related Mesh Headings: Hyperinsulinism; Nonsuppressible Insulin-Like Activity; Proinsulin; Receptor, Insulin;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Hypoglycemic Agents;

Tree Number: D06.472.699.587.740.625; D12.644.548.586.740.625;

Technical Notes: /blood: consider also HYPERINSULINEMIA (excessively high blood insulin levels) but do not confuse with HYPERINSULINISM (excessive secretion of insulin by pancreas); /immunology: consider also INSULIN ANTIBODIES; precursor = PROINSULIN; INSULIN INFUSION SYSTEMS is available