Insulin-Like Growth Factor I - Research News and Information

Saturday, January 10, 2009

Low dose beta-blocker prevents ovariectomy-induced bone loss in rats without affecting heart functions.

29 Nov 2008 Findings from animal studies have suggested that bone remodeling is under beta-adrenergic control. However, the level of adrenergic inhibition required to achieve the most favorable effects on the skeleton remains unknown. To address this question, ... Read more...

Modulation of Na+-H+ exchange isoforms NHE1 and NHE3 by insulin-like growth factor-1 in isolated bovine articular chondrocytes.

30 Oct 2008 Incubation with serum modulates the transporters that regulate intracellular pH (pH(i)) in articular chondrocytes, upregulating acid extrusion by Na(+)-H(+) exchange (NHE). There is stimulation of NHE1, together with induction of NHE3 activity. ... Read more...

Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells.

30 Oct 2008 Advanced age is a major risk factor for atherosclerosis, but how aging per se influences pathogenesis is not clear. Insulin-like growth factor-1 receptor (IGF-1R) promotes aortic vascular smooth muscle cell (VSMC) growth, migration, and ... Read more...

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Latest indexed articles for 'Insulin-Like Growth Factor I'

These are the very latest articles for this heading:

• Low dose beta-blocker prevents ovariectomy-induced bone loss in rats without affecting heart functions. 29 Nov 2008
• Modulation of Na+-H+ exchange isoforms NHE1 and NHE3 by insulin-like growth factor-1 in isolated bovine articular chondrocytes. 30 Oct 2008
• Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells. 30 Oct 2008
• Turning anti-ageing genes against cancer. 30 Oct 2008
• Single administration of thrombopoietin prevents progression of liver fibrosis and promotes liver regeneration after partial hepatectomy in cirrhotic rats. 30 Oct 2008
• [Pregnancy in active acromegaly] 26 Oct 2008
• Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies. 5 Oct 2008
• Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice. 30 Sep 2008
• Developmental changes and the impact of isoflavones on mRNA expression of IGF-I receptor, EGF receptor and related growth factors in porcine skeletal muscle cell cultures. 29 Sep 2008
• Hypophysectomy for prostate cancer: a revival of old knowledge? 29 Sep 2008
• SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans. 29 Sep 2008
• Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. 29 Sep 2008
• Nedd4 controls animal growth by regulating IGF-1 signaling. 21 Sep 2008
• Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1. 14 Sep 2008
• Systemic IGF-I administration stimulates the in vivo growth of early, but not advanced, renal cell carcinoma. 13 Sep 2008
• No association between a polymorphic variant of the IRS-1 gene and prostate cancer risk. 13 Sep 2008
• Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and risk of benign prostate hyperplasia in the prostate cancer prevention trial. 13 Sep 2008
• IGF1 is a modifier of disease risk in hereditary non-polyposis colorectal cancer. 13 Sep 2008
• Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves' disease. 13 Sep 2008
• Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer. 7 Sep 2008

See a longer list of these articles.

Technical information about 'Insulin-Like Growth Factor I'

Definition: A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.

Chemical name: Insulin-like growth factor I

Registry Number: 67763-96-6

Descriptor UI: D007334

Alternative terms: Insulin-Like Growth Factor I; Insulin-Like Somatomedin Peptide I; Insulin Like Somatomedin Peptide I; Somatomedin C; IGF-I-SmC; IGF-1; IGF-I; Insulin Like Growth Factor I;

Related Mesh Headings: Receptor, IGF Type 1;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.937.400; D12.776.124.862.400; D12.776.467.937.400; D23.529.937.400;

History Note: 91(86); was see under SOMATOMEDINS 1986-90