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Insulin
Research News and Information
Definition of 'Insulin'A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). |
Saturday, November 07, 2009
Functional role of aquaglyceroporin 7 expression in the pancreatic beta-cell line BRIN-BD11.
30 Oct 2009 
Both mouse and rat pancreatic islet beta-cells were recently found to express aquaglyceroporin 7 (AQP7). In the present study, the expression and role of AQP7 in the function of BRIN-BD11 cells were investigated. AQP7 mRNA and protein were detected ... Read more...
Three-year efficacy of complex insulin regimens in type 2 diabetes.
20 Oct 2009 BACKGROUND: Evidence supporting the addition of specific insulin regimens to oral therapy in patients with type 2 diabetes mellitus is limited. METHODS: In this 3-year open-label, multicenter trial, we evaluated 708 patients who had suboptimal ... Read more...
Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart.
10 Oct 2009 Mitochondrial respiration/oxidative phosphorylation is the main source of energy, in the form of ATP, in the heart under physiological conditions. Different respiratory substrates were used in various experiments during heart perfusion: glucose, ... Read more...
Latest indexed articles for 'Insulin'
These are the very latest articles for this heading:
- Insulin drips or glucose control for burn patients.
30 Oct 2009 - Functional role of aquaglyceroporin 7 expression in the pancreatic beta-cell line BRIN-BD11. 30 Oct 2009
- Three-year efficacy of complex insulin regimens in type 2 diabetes. 20 Oct 2009
- Optimal insulin treatment in type 2 diabetes. 20 Oct 2009
- Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart. 10 Oct 2009
- Using effectiveness and cost-effectiveness to make drug coverage decisions: a comparison of Britain, Australia, and Canada. 5 Oct 2009
- Diabetes and the public's health. Oct 2009
- Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. 30 Sep 2009
- Leukocytoclastic vasculitis associated with insulin aspart in a patient with type 2 diabetes. 29 Sep 2009
- Cardiometabolic risk in younger and older adults across an index of ambulatory activity. 29 Sep 2009
- Comparison of preservation solutions in an experimental model of organ cooling in kidney transplantation. 29 Sep 2009
- Time-dependent insulin oligomer reaction pathway prior to fibril formation: cooling and seeding. 29 Sep 2009
- Transport stress in broilers: I. Blood metabolism, glycolytic potential, and meat quality. 29 Sep 2009
- Effect of the HMG-CoA reductase inhibitor rosuvastatin on early chronic kidney injury in obese zucker rats fed with an atherogenic diet. 29 Sep 2009
- Current advances and travails in islet transplantation. 29 Sep 2009
- Early Origins of polycystic ovary syndrome: hypotheses may change without notice. 29 Sep 2009
- Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. 29 Sep 2009
- Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. 29 Sep 2009
- Therapies for type 2 diabetes and coronary artery disease. 29 Sep 2009
- A multicenter, randomized trial of treatment for mild gestational diabetes. 29 Sep 2009
See a longer list of these articles.
Technical information about 'Insulin'
Definition: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Chemical name: Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-
Registry Number: 11061-68-0
Descriptor UI: D007328
Alternative terms: Insulin; Insulin, Regular; Regular Insulin; Humulin S; Iletin; Insulin A Chain; Insulin, Globin Zinc; Globin Zinc Insulin; Velosulin; Insulin, Regular, Human; Insulin, Regular, Pork; Novolin; Sodium Insulin; Insulin, Sodium; Type I Insulin; Insulin, Type I; Type II Insulin; Insulin, Type II; Humulin; Insulin, Regular, Beef-Pork;
Related Mesh Headings: Hyperinsulinism; Nonsuppressible Insulin-Like Activity; Proinsulin; Receptor, Insulin;
Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;
Pharmacological Action: Hypoglycemic Agents;
Tree Number: D06.472.699.587.740.625; D12.644.548.586.740.625;
Technical Notes: /blood: consider also HYPERINSULINEMIA (excessively high blood insulin levels) but do not confuse with HYPERINSULINISM (excessive secretion of insulin by pancreas); /immunology: consider also INSULIN ANTIBODIES; precursor = PROINSULIN; INSULIN INFUSION SYSTEMS is available