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Insulin
Research News and Information
Definition of 'Insulin'A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). |
Saturday, November 21, 2009
Intracellular presence of insulin and its phosphorylated receptor in non-small cell lung cancer.
29 Nov 2009 
Insulin has been known for a long time to influence the growth and differentiation of normal and transformed cells. In order to delineate the role of insulin specifically in non-small cell lung cancer (NSCLC), we have now searched by ... Read more...
Kinetics of transport and phosphorylation of glucose in cancer cells.
29 Nov 2009 Metabolic control analysis of tumor glycolysis has indicated that hexokinase (HK) and glucose transporter (GLUT) exert the main flux control (71%). To understand why they are the main controlling steps, the GLUT and HK kinetics and the contents of ... Read more...
29 Nov 2009 The osteo-anabolic effects of intermittent parathyroid hormone (PTH) treatment require insulin-like growth factor (IGF) signaling through the IGF-I receptor. A major downstream target of the IGF-I receptor (via Akt) is the mammalian target of ... Read more...
Latest indexed articles for 'Insulin'
These are the very latest articles for this heading:
- Intracellular presence of insulin and its phosphorylated receptor in non-small cell lung cancer. 29 Nov 2009
- Kinetics of transport and phosphorylation of glucose in cancer cells. 29 Nov 2009
- Rapamycin impairs trabecular bone acquisition from high-dose but not low-dose intermittent parathyroid hormone treatment. 29 Nov 2009
- Repeated measures of serum glucose and insulin in relation to postmenopausal breast cancer. 29 Nov 2009
- Images in clinical medicine. Injection-site lipoatrophy.
3 Nov 2009 - Insulin2 gene (Ins2) transcription by NOD bone marrow-derived cells does not influence autoimmune diabetes development in NOD-Ins2 knockout mice. 30 Oct 2009
- Effect of adipose tissue on the sexual dimorphism in metabolic flexibility. 30 Oct 2009
- Mechanisms of impaired glucose tolerance and insulin secretion during isoflurane anesthesia. 30 Oct 2009
- All glucose measurements are not equal. 30 Oct 2009
- A(1c) control in a primary care setting: self-titrating an insulin analog pre-mix (INITIATEplus trial). 30 Oct 2009
- Insulin drips or glucose control for burn patients. 30 Oct 2009
- Functional role of aquaglyceroporin 7 expression in the pancreatic beta-cell line BRIN-BD11. 30 Oct 2009
- Three-year efficacy of complex insulin regimens in type 2 diabetes. 20 Oct 2009
- Optimal insulin treatment in type 2 diabetes. 20 Oct 2009
- Thighs and heart disease. Exercise, muscle mass, and insulin sensitivity. 19 Oct 2009
- New insights into cardiac aging. 10 Oct 2009
- Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone. 10 Oct 2009
- Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart. 10 Oct 2009
- Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice. 7 Oct 2009
- Using effectiveness and cost-effectiveness to make drug coverage decisions: a comparison of Britain, Australia, and Canada. 5 Oct 2009
See a longer list of these articles.
Technical information about 'Insulin'
Definition: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Chemical name: Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-
Registry Number: 11061-68-0
Descriptor UI: D007328
Alternative terms: Insulin; Insulin, Regular; Regular Insulin; Humulin S; Iletin; Insulin A Chain; Insulin, Globin Zinc; Globin Zinc Insulin; Velosulin; Insulin, Regular, Human; Insulin, Regular, Pork; Novolin; Sodium Insulin; Insulin, Sodium; Type I Insulin; Insulin, Type I; Type II Insulin; Insulin, Type II; Humulin; Insulin, Regular, Beef-Pork;
Related Mesh Headings: Hyperinsulinism; Nonsuppressible Insulin-Like Activity; Proinsulin; Receptor, Insulin;
Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;
Pharmacological Action: Hypoglycemic Agents;
Tree Number: D06.472.699.587.740.625; D12.644.548.586.740.625;
Technical Notes: /blood: consider also HYPERINSULINEMIA (excessively high blood insulin levels) but do not confuse with HYPERINSULINISM (excessive secretion of insulin by pancreas); /immunology: consider also INSULIN ANTIBODIES; precursor = PROINSULIN; INSULIN INFUSION SYSTEMS is available