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Integrins - Research News and Information
Saturday, January 10, 2009
Definition of 'Integrins'A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation. |
29 Nov 2008 
BACKGROUND: Cell adhesion plays an important role in proliferation, metastasis, and tumor growth and may represent a potential vulnerability in treatment of prostate cancer patients. Bicalutamide (Casodex) has been used as an anti-androgen agent ... Read more...
30 Oct 2008 Focal adhesion kinase (FAK) plays key roles in cell adhesion and migration. We now report that the delayed rectifier Kv2.1 potassium channel, through its LD-like motif in N-terminus, may interact with FAK and enhance phosphorylation of FAK(397) and ... Read more...
Regulation of angiogenesis: apoptotic cues from the ECM.
28 Oct 2008 The extracellular matrix (ECM) acts both as a physical scaffold for cells and as a repository for growth factors. Moreover, ECM structure and physical-chemical properties convey precise information to cells that profoundly influences their biology ... Read more...
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Latest indexed articles for 'Integrins'
These are the very latest articles for this heading:
- Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation. 29 Nov 2008
- Formation of Kv2.1-FAK complex as a mechanism of FAK activation, cell polarization and enhanced motility. 30 Oct 2008
- What the lung has taught us about latent TGF-beta activation.
30 Oct 2008 - Regulation of angiogenesis: apoptotic cues from the ECM. 28 Oct 2008
- Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms. 25 Oct 2008
- Nanopatterning of fibronectin and the influence of integrin clustering on endothelial cell spreading and proliferation. 29 Sep 2008
- Interactions between integrin ligand density and cytoskeletal integrity regulate BMSC chondrogenesis. 29 Sep 2008
- Selective amino acid restriction differentially affects the motility and directionality of DU145 and PC3 prostate cancer cells. 29 Sep 2008
- Integrin binding immunoglobulin type filamin domains have variable stability. 24 Sep 2008
- The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. 20 Sep 2008
- Suppression of integrin alphaupsilonbeta6 by RNA interference in colon cancer cells inhibits extracellular matrix degradation through the MAPK pathway. 13 Sep 2008
- Cutting edge: instructive role of peripheral tissue cells in the imprinting of T cell homing receptor patterns. 13 Sep 2008
- Alpha4beta7/MAdCAM-1 interactions play an essential role in transitioning cryptopatches into isolated lymphoid follicles and a nonessential role in cryptopatch formation. 13 Sep 2008
- Kindlin-3: a new gene involved in the pathogenesis of LAD-III. 13 Sep 2008
- EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. 13 Sep 2008
- Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization. 13 Sep 2008
- Resolving sub-diffraction limit encounters in nanoparticle tracking using live cell plasmon coupling microscopy. 11 Sep 2008
- In vivo positron emission tomography (PET) imaging with an alphavbeta6 specific peptide radiolabeled using 18F-"click" chemistry: evaluation and comparison with the corresponding 4-[18F]fluorobenzoyl- and 2-[18F]fluoropropionyl-peptides. 10 Sep 2008
- What underlies endothelial shear sensing? The matrix, of course. 10 Sep 2008
- Long exposure of non-cytotoxic concentrations of methylselenol suppresses the invasive potential of B16F10 melanoma. 30 Aug 2008
See a longer list of these articles.
Technical information about 'Integrins'
Definition: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Registry Number: 0
Descriptor UI: D016023
Alternative terms: Integrins;
Related Mesh Headings: Cell Adhesion Molecules;
Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists; cerebrospinal fluid;
Tree Number: D12.776.543.750.705.408;
History Note: 90
Technical Notes: prefer specifics