Intercellular Signaling Peptides and Proteins - Research News and Information

Saturday, January 10, 2009

Acquired cisplatin resistance in the head-neck cancer cell line Cal27 is associated with decreased DKK1 expression and can partially be reversed by overexpression of DKK1.

30 Oct 2008 Head and neck cancers are treated by a combination of surgery, radiotherapy and/or chemotherapy. The clinical success of cisplatin-based chemotherapy, mostly in combination with 5-FU or a taxane, is however limited by multifactorial intrinsic or ... Read more...

Down-regulation of inhibition of differentiation-1 via activation of activating transcription factor 3 and Smad regulates REIC/Dickkopf-3-induced apoptosis.

13 Oct 2008 REIC/Dickkopf-3 (Dkk-3), a tumor suppressor gene, has been investigated in gene therapy studies. Our previous study suggested that REIC/Dkk-3-induced apoptosis mainly resulted from phosphorylation of c-Jun-NH(2) kinase (JNK) in prostate cancer ... Read more...

NK cells and cancer immunosurveillance.

7 Oct 2008 Natural killer (NK) cells are lymphocytes of the innate immune system that monitor cell surfaces of autologous cells for an aberrant expression of MHC class I molecules and cell stress markers. Since their first description more than 30 years ago, ... Read more...

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Latest indexed articles for 'Intercellular Signaling Peptides and Proteins'

These are the very latest articles for this heading:

• Acquired cisplatin resistance in the head-neck cancer cell line Cal27 is associated with decreased DKK1 expression and can partially be reversed by overexpression of DKK1. 30 Oct 2008
• Down-regulation of inhibition of differentiation-1 via activation of activating transcription factor 3 and Smad regulates REIC/Dickkopf-3-induced apoptosis. 13 Oct 2008
• NK cells and cancer immunosurveillance. 7 Oct 2008
• NKG2D ligands in tumor immunity. 7 Oct 2008
• Progranulin variability has no major role in Parkinson disease genetic etiology. 5 Oct 2008
• Chemotaxis of human articular chondrocytes and mesenchymal stem cells. 29 Sep 2008
• Paracrine inhibition of osteoblast differentiation induced by neuroblastoma cells. 29 Sep 2008
• The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis. 29 Sep 2008
• Cytokines and growth factors and thyroid hormone. 29 Sep 2008
• Regulation and consequences of differential gene expression in diabetic kidney disease. 29 Sep 2008
• Evaluation of novel cyclic analogues of apelin. 29 Sep 2008
• The hepatic apelin system: a new therapeutic target for liver disease. 29 Sep 2008
• Diverse cell signaling events modulated by perlecan. 29 Sep 2008
• Role of TGF-beta and FGF in the treatment of radiation-impaired wounds using a novel drug delivery system. 29 Sep 2008
• A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. 29 Sep 2008
• Gene symbol: JAG1. Disease: Alagille syndrome. 29 Sep 2008
• Gene symbol: JAG1. Disease: Alagille syndrome. 29 Sep 2008
• Gene symbol: JAG1. Disease: Alagille syndrome. 29 Sep 2008
• Heparin-binding epidermal growth factor-like growth factor promotes transcoelomic metastasis in ovarian cancer through epithelial-mesenchymal transition. 29 Sep 2008
• Anti-epidermal growth factor receptor strategies for advanced breast cancer. 29 Sep 2008

See a longer list of these articles.

Technical information about 'Intercellular Signaling Peptides and Proteins'

Definition: Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.

Registry Number: 0

Descriptor UI: D036341

Alternative terms: Intercellular Signaling Peptides and Proteins; Paracrine Peptide Factors; Peptide Factors, Paracrine; Paracrine Protein Factors; Growth Factors;

Related Mesh Headings: Receptors, Growth Factor; Paracrine Communication; Peptide Hormones;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276; D12.776.467; D23.529;

History Note: 2003; for GROWTH FACTORS use GROWTH SUBSTANCES 1999-2006

Technical Notes: general or unspecified; prefer specifics; coordinate with PARACRINE COMMUNICATION if pertinent; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS is also available