Interleukin-13
Research News and Information

Tuesday, March 16, 2010

Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells.

13 Oct 2009 IL-33, a new member of the IL-1 cytokine family, promotes Th2 inflammation, but evidence on the implications of this cytokine in asthma is lacking. IL-33 would be mainly expressed by structural cells, but whether proinflammatory cytokines modulate ... Read more...

Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.

29 Sep 2009 BACKGROUND: Atopic dermatitis (AD) is characterized by local and systemic T(H)2 responses to cutaneously introduced allergens and is a risk factor for asthma. Blockade of T(H)2 cytokines has been suggested as therapy for AD. OBJECTIVES: We sought to ... Read more...

Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.

19 Sep 2009 Polymorphisms in the interleukin-4 receptor alpha chain (IL-4R alpha) have been linked to asthma incidence and severity, but a causal relationship has remained uncertain. In particular, a glutamine to arginine substitution at position 576 (Q576R) of ... Read more...

Latest indexed articles for 'Interleukin-13'

These are the very latest articles for this heading:

• Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. 13 Oct 2009
• Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. 29 Sep 2009
• Editorial: Basophil survival and immunomodulatory function are uniquely regulated by a novel MyD88-dependent pathway. 29 Sep 2009
• Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. 19 Sep 2009
• Common genetic variants and risk for non-Hodgkin lymphoma and adult T-cell lymphoma/leukemia in Jamaica. 13 Sep 2009
• IL-13-induced oxidative stress via microglial NADPH oxidase contributes to death of hippocampal neurons in vivo. 12 Sep 2009
• Elastase- and LPS-exposed mice display altered responses to rhinovirus infection. 9 Sep 2009
• Analytical validation of a highly sensitive microparticle-based immunoassay for the quantitation of IL-13 in human serum using the Erenna immunoassay system. 31 Aug 2009
• Human pharmacokinetics/pharmacodynamics of an interleukin-4 and interleukin-13 dual antagonist in asthma. 30 Aug 2009
• Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma. 30 Aug 2009
• Cytokine modulation of atopic dermatitis filaggrin skin expression. 30 Aug 2009
• Disruption of Th2 immunity results in a gender-specific expansion of IL-13 producing accessory NK cells during helminth infection. 17 Aug 2009
• Regulation of Fcgamma receptors and immunoglobulin G-mediated phagocytosis in mouse microglia. 9 Aug 2009
• Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma. 6 Aug 2009
• Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy. 6 Aug 2009
• Effect of betamethasone phosphate loaded polymeric nanoparticles on a murine asthma model. 2 Aug 2009
• Pinellia ternata, Citrus reticulata, and their combinational prescription inhibit eosinophil infiltration and airway hyperresponsiveness by suppressing CCR3+ and Th2 cytokines production in the ovalbumin-induced asthma model. 31 Jul 2009
• Keratinocytes treated with peptidoglycan from Staphylococcus aureus produce vascular endothelial growth factor, and its expression is amplified by the subsequent production of interleukin-13. 30 Jul 2009
• Regulation of mucin expression in respiratory diseases. 30 Jul 2009
• Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Interleukin-13'

Definition: A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.

Registry Number: 0

Descriptor UI: D018793

Alternative terms: Interleukin-13; IL-13; Interleukin 13; IL 13; IL13;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.374.465.513; D12.776.467.374.465.513; D23.529.374.465.513;

Online Note: use INTERLEUKIN-13 (NM) to search INTERLEUKIN 13 1993-94

History Note: 95; was INTERLEUKIN 13 (NM) 1993-94

Technical Notes: DF: IL 13 or IL13