Interleukins
Research News and Information

Sunday, November 22, 2009

Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells.

13 Oct 2009 IL-33, a new member of the IL-1 cytokine family, promotes Th2 inflammation, but evidence on the implications of this cytokine in asthma is lacking. IL-33 would be mainly expressed by structural cells, but whether proinflammatory cytokines modulate ... Read more...

CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus.

6 Oct 2009 How cell type-specific differences in chromatin conformation are achieved and their contribution to gene expression are incompletely understood. Here we identify a cryptic upstream orchestrator of interferon-gamma (IFNG) transcription, which is ... Read more...

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus.

6 Oct 2009 Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States, with estimates of 4 million HCV-infected individuals in the United States and 170 million worldwide. Most (70-80%) HCV infections persist and about 30% ... Read more...

Latest indexed articles for 'Interleukins'

These are the very latest articles for this heading:

• Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. 13 Oct 2009
• CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. 6 Oct 2009
• Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. 6 Oct 2009
• Involvement of interleukin-15 and interleukin-21, two gamma-chain-related cytokines, in celiac disease. 5 Oct 2009
• IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. 29 Sep 2009
• IL-12 and type I IFN response of neonatal myeloid DC to human CMV infection. 29 Sep 2009
• Editorial: Basophil survival and immunomodulatory function are uniquely regulated by a novel MyD88-dependent pathway. 29 Sep 2009
• Effects of salivary gland homogenate from wild-caught and laboratory-reared Lutzomyia longipalpis on the evolution and immunomodulation of Leishmania (Leishmania) amazonensis infection. 29 Sep 2009
• Differential effect of IL-27 on developing versus committed Th17 cells. 26 Sep 2009
• Translating inflammatory bowel disease research into clinical medicine. 16 Sep 2009
• Genomics: Hepatitis C virus gets personal. 15 Sep 2009
• IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. 11 Sep 2009
• Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. 11 Sep 2009
• Interferon-alfa, interferon-lambda and hepatitis C. 11 Sep 2009
• IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. 9 Sep 2009
• TLR3 ligand polyinosinic:polycytidylic acid induces IL-17A and IL-21 synthesis in human Th cells. 9 Sep 2009
• Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. 4 Sep 2009
• Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. 30 Aug 2009
• Methylprednisolone therapy in deceased donors reduces inflammation in the donor liver and improves outcome after liver transplantation. 30 Aug 2009
• Genetic modification of T cells with IL-21 enhances antigen presentation and generation of central memory tumor-specific cytotoxic T-lymphocytes. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Interleukins'

Definition: Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.

Registry Number: 0

Descriptor UI: D007378

Alternative terms: Interleukins; Interleukin;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.374.465; D12.776.467.374.465; D23.529.374.465;

History Note: 1988; for MITOGENIC FACTORS, LYMPHOCYTE use INTERLEUKIN-2 1983-2001, LYMPHOKINES 1978-1982

Technical Notes: general or unspecified; prefer specifics