Intracellular Signaling Peptides and Proteins - Metabolism
Research News and Information

Sunday, November 22, 2009

p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.

29 Nov 2009 The stress protein p8 is a small, highly basic, unfolded, and multifunctional protein. We have previously shown that most of its functions are exerted through interactions with other proteins, whose activities are thereby enhanced or repressed. In ... Read more...

Membrane-dependent bystander effect contributes to amplification of the response to alpha-particle irradiation in targeted and nontargeted cells.

13 Nov 2009 PURPOSE: Free radicals are believed to play an active role in the bystander response. This study investigated their origin as well as their temporal and spatial impacts in the bystander effect. METHODS AND MATERIALS: We employed a precise ... Read more...

The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity.

13 Nov 2009 Hepatocellular carcinoma (HCC) is the fifth most commonly occurring cancer worldwide. The expression of p27 has been related to reduced severity of tumor grade and recurrence of HCC. The study assessed the role of p27 on the cell proliferation and ... Read more...

Latest indexed articles for 'Intracellular Signaling Peptides and Proteins - Metabolism'

These are the very latest articles for this heading:

• p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage. 29 Nov 2009
• Membrane-dependent bystander effect contributes to amplification of the response to alpha-particle irradiation in targeted and nontargeted cells. 13 Nov 2009
• The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity. 13 Nov 2009
• Expression and role of adrenomedullin in renal tumors and value of its mRNA levels as prognostic factor in clear-cell renal carcinoma. 13 Nov 2009
• Upregulated p27kip1 can downregulate survivin expression and inhibit telomerase activity in gastric carcinoma cells. 30 Oct 2009
• Temperature entrainment of Drosophila's circadian clock involves the gene nocte and signaling from peripheral sensory tissues to the brain. 27 Oct 2009
• Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord. 19 Oct 2009
• Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless. 14 Oct 2009
• Ferrying wingless across the synaptic cleft. 14 Oct 2009
• Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking. 12 Oct 2009
• Daily electrical silencing in the mammalian circadian clock. 7 Oct 2009
• Proteomic and genetic approaches identify Syk as an AML target. 4 Oct 2009
• Can treating the SYK cell cure leukemia? 4 Oct 2009
• Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. 3 Oct 2009
• 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. 30 Sep 2009
• A heritable switch in carbon source utilization driven by an unusual yeast prion. 29 Sep 2009
• T cell receptor signaling induced by an analog peptide of type II collagen requires activation of Syk. 29 Sep 2009
• Nemo-like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells. 29 Sep 2009
• Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors. 29 Sep 2009
• FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response. 26 Sep 2009

See a longer list of these articles.

Technical information about 'Intracellular Signaling Peptides and Proteins'

Definition: Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.

Registry Number: 0

Descriptor UI: D047908

Alternative terms: Intracellular Signaling Peptides and Proteins; Intracellular Signaling Proteins; Proteins, Intracellular Signaling; Signaling Proteins, Intracellular; Intracellular Signaling Peptides; Peptides, Intracellular Signaling; Signaling Peptides, Intracellular;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.360; D12.776.476;

History Note: 2005

Technical Notes: don't confuse with SIGNAL PEPTIDES entry term to PROTEIN SORTING SIGNALS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS is also available