Intracellular Signaling Peptides and Proteins - Research News and Information

Saturday, January 10, 2009

Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5.

29 Nov 2008 Mitogen-activated protein (MAP) kinases are typical examples of protein kinases whose enzymatic activity is mainly controlled by activation loop phosphorylation. The classical MAP kinases ERK1/ERK2, JNK, p38 and ERK5 all contain the conserved ... Read more...

Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival.

13 Nov 2008 The tumour suppressor gene (TSG) LIM domain containing protein 1 (LIMD1) has been associated with transformation of epithelial cells of the lung and its expression is downregulated in all lung tumour samples tested compared to normal lung matched ... Read more...

S10 phosphorylation of p27 mediates atRA induced growth arrest in ovarian carcinoma cell lines.

30 Oct 2008 All trans retinoic acid (atRA) has been shown to inhibit the growth of CAOV3 ovarian carcinoma cells and to elevate the level of p27 cyclin-dependent kinase inhibitor. We report here that phosphorylation at S10 residue is an important event in ... Read more...

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Latest indexed articles for 'Intracellular Signaling Peptides and Proteins'

These are the very latest articles for this heading:

• Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. 29 Nov 2008
• Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival. 13 Nov 2008
• S10 phosphorylation of p27 mediates atRA induced growth arrest in ovarian carcinoma cell lines. 30 Oct 2008
• Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase. 22 Oct 2008
• Brothers and sisters: molecular insights into arterial-venous heterogeneity. 22 Oct 2008
• Optical switches for remote and noninvasive control of cell signaling. 15 Oct 2008
• Comment on "Molecular basis of the dual functions of 2B4 (CD244)". 13 Oct 2008
• Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1. 13 Oct 2008
• Mutation and copy number analysis of LNX1 and Numbl in nervous system tumors. 13 Oct 2008
• FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. 12 Oct 2008
• Branching morphogenesis. 8 Oct 2008
• Immunology: Helpful T cells are sticky. 7 Oct 2008
• SAP-controlled T-B cell interactions underlie germinal centre formation. 7 Oct 2008
• Context-dependent requirement for dE2F during oncogenic proliferation. Oct 2008
• Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization. Oct 2008
• Hypothalamic orexins/hypocretins as regulators of breathing. 30 Sep 2008
• Up-regulation of activating transcription factor-5 suppresses SAP expression to activate T cells in hemophagocytic syndrome associated with Epstein-Barr virus infection and immune disorders. 30 Sep 2008
• Lipid droplet-associated proteins protect renal tubular cells from fatty acid-induced apoptosis. 30 Sep 2008
• Structural and dynamical studies of Humanin in water and TFE/water mixture: a molecular dynamics simulation. 29 Sep 2008
• The new tumor suppressor genes ING: genomic structure and status in cancer. 29 Sep 2008

See a longer list of these articles.

Technical information about 'Intracellular Signaling Peptides and Proteins'

Definition: Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.

Registry Number: 0

Descriptor UI: D047908

Alternative terms: Intracellular Signaling Peptides and Proteins; Intracellular Signaling Proteins; Proteins, Intracellular Signaling; Signaling Proteins, Intracellular; Intracellular Signaling Peptides; Peptides, Intracellular Signaling; Signaling Peptides, Intracellular;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.360; D12.776.476;

History Note: 2005

Technical Notes: don't confuse with SIGNAL PEPTIDES entry term to PROTEIN SORTING SIGNALS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS is also available