Ion Channel Gating - Research News and Information

Saturday, January 10, 2009

The effects of volatile aromatic anesthetics on voltage-gated Na+ channels expressed in Xenopus oocytes.

30 Oct 2008 BACKGROUND: Many inhaled anesthetics inhibit voltage-gated sodium channels at clinically relevant concentrations, and suppression of neurotransmitter release by these anesthetics results, at least partly, from decreased presynaptic sodium channel ... Read more...

Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis.

30 Sep 2008 Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system that results in persistent impairment in young adults. During chronic progressive disease stages, there is a strong correlation between neurodegeneration and ... Read more...

From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales.

26 Sep 2008 Computer simulations of electrical behaviour in the whole ventricles have become commonplace during the last few years. The goals of this article are (i) to review the techniques that are currently employed to model cardiac electrical activity in ... Read more...

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Latest indexed articles for 'Ion Channel Gating'

These are the very latest articles for this heading:

• The effects of volatile aromatic anesthetics on voltage-gated Na+ channels expressed in Xenopus oocytes. 30 Oct 2008
• Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis. 30 Sep 2008
• From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales. 26 Sep 2008
• AMPA receptor subunit-specific regulation by a distinct family of type II TARPs. 23 Sep 2008
• Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation. 20 Sep 2008
• Structures of pseudechetoxin and pseudecin, two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels: implications for movement of the C-terminal cysteine-rich domain. 17 Sep 2008
• A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P(2). 12 Sep 2008
• Large-scale movement within the voltage-sensor paddle of a potassium channel-support for a helical-screw motion. 9 Sep 2008
• A novel Na+ channel splice form contributes to the regulation of an androgen-dependent social signal. 8 Sep 2008
• Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome. 3 Sep 2008
• The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating. 3 Sep 2008
• Insight toward epithelial Na+ channel mechanism revealed by the acid-sensing ion channel 1 structure. 30 Aug 2008
• Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets. 30 Aug 2008
• A hypothesis on the origin and evolution of the response to inhaled anesthetics. 30 Aug 2008
• Why can all of biology be anesthetized? 30 Aug 2008
• Does natural selection explain the universal response of metazoans to volatile anesthetics? 30 Aug 2008
• Meyer and Overton revisited. 30 Aug 2008
• Preventing voltage-dependent gating of anthrax toxin channels using engineered disulfides. 30 Aug 2008
• A carboxy-terminal inter-helix linker as the site of phosphatidylinositol 4,5-bisphosphate action on Kv7 (M-type) K+ channels. 30 Aug 2008
• Mutations of nonconserved residues within the calcium channel alpha1-interaction domain inhibit beta-subunit potentiation. 30 Aug 2008

See a longer list of these articles.

Technical information about 'Ion Channel Gating'

Definition: The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.

Descriptor UI: D015640

Alternative terms: Ion Channel Gating; Gating, Ion Channel; Gatings, Ion Channel; Ion Channel Gatings;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G02.111.087.800.400; G02.149.115.800.400; G04.299.500; G04.299.880.400; G07.265.337.500; G07.700.240.500;

History Note: 90

Technical Notes: do not confuse with SENSORY GATING