Isoenzymes - Genetics
Research News and Information

Monday, November 23, 2009

Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts.

29 Nov 2009 The receptor activator of nuclear factor-kappaB ligand (RANKL) plays a critical role in the differentiation and bone resorptive activity of osteoclasts. Recently, the development of anti-resorptive agents from natural substances has become a subject ... Read more...

Titanium IV ions induced human osteoclast differentiation and enhanced bone resorption in vitro.

29 Sep 2009 There is increasing evidence that titanium (Ti) ions are released from orthopedic implants, with concentrations in the range of 1 microM in tissue and blood, and may play a role in aseptic loosening of orthopedic implants. This study investigated ... Read more...

Silencing the SPCA1 (secretory pathway Ca2+-ATPase isoform 1) impairs Ca2+ homeostasis in the Golgi and disturbs neural polarity.

28 Sep 2009 Neural cell differentiation involves a complex regulatory signal transduction network in which Ca(2+) ions and the secretory pathway play pivotal roles. The secretory pathway Ca(2+)-ATPase isoform 1 (SPCA1) is found in the Golgi apparatus where it ... Read more...

Latest indexed articles for 'Isoenzymes - Genetics'

These are the very latest articles for this heading:

• Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts. 29 Nov 2009
• Cyclin-dependent kinases: a family portrait. 30 Oct 2009
• Titanium IV ions induced human osteoclast differentiation and enhanced bone resorption in vitro. 29 Sep 2009
• Silencing the SPCA1 (secretory pathway Ca2+-ATPase isoform 1) impairs Ca2+ homeostasis in the Golgi and disturbs neural polarity. 28 Sep 2009
• Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning. 28 Sep 2009
• Cloning and epitope mapping of Cry11Aa-binding sites in the Cry11Aa-receptor alkaline phosphatase from Aedes aegypti. 20 Sep 2009
• Physiology and posttranscriptional regulation of methanol:coenzyme M methyltransferase isozymes in Methanosarcina acetivorans C2A. 16 Sep 2009
• Interactions between large and small subunits of different acetohydroxyacid synthase isozymes of Escherichia coli. 13 Sep 2009
• A novel variant of ferredoxin-dependent sulfite reductase having preferred substrate specificity for nitrite in the unicellular red alga Cyanidioschyzon merolae. 12 Sep 2009
• Specific role of phosphoinositide 3-kinase p110alpha in the regulation of phagocytosis and pinocytosis in macrophages. 12 Sep 2009
• Adenylyl cyclase type 5 protein expression during cardiac development and stress. 2 Sep 2009
• aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. 31 Aug 2009
• Identification of domains involved in the allosteric regulation of cytosolic Arabidopsis thaliana NADP-malic enzymes. 31 Aug 2009
• Comparative characterization of a temperature responsive gene (lactate dehydrogenase-B, ldh-b) in two congeneric tropical fish, Lates calcarifer and Lates niloticus. 30 Aug 2009
• Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil. 30 Aug 2009
• Comment on "The emerging roles of cystatins in Alzheimer's disease". DOI 10.1002/bies.200900012. 30 Aug 2009
• The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: a case-control study in the Portuguese population. 30 Aug 2009
• NADPH oxidase NOX2 mediates rapid cellular oxidation following ATP stimulation of endotoxin-primed macrophages. 30 Aug 2009
• The Akt kinases: isoform specificity in metabolism and cancer. 21 Aug 2009
• Role of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts. 20 Aug 2009

See a longer list of these articles.

Technical information about 'Isoenzymes'

Definition: Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.

Registry Number: 0

Descriptor UI: D007527

Alternative terms: Isoenzymes; Isozymes; Alloenzymes; Allozymes;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.348; D12.776.800.300;

History Note: 67(65)

Technical Notes: IM general only; coordinate NIM with specific enzyme (IM)