Isoxazoles - Pharmacology
Research News and Information

Monday, November 23, 2009

Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition.

6 Sep 2009 This investigation addressed the paradox that disintegrins and small RGD-ligands readily bind to the resting alphaIIbbeta3 integrin, while macromolecules with similar integrin recognition motifs require an activated, or primed, receptor. Three ... Read more...

Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells.

30 Aug 2009 Human mesenchymal stem cells (MSCs) from bone marrow stroma can home to and repair injured tissue, but the rate of engraftment is generally low. Regulating migration-related signaling of MSCs may be a powerful strategy to enhance this process. To ... Read more...

XN05, a novel synthesized microtubule inhibitor, exhibits potent activity against human carcinoma cells in vitro.

Aug 2009 The present data showed that a novel synthesized compound, N-acetyl-N-(4-(4-methoxyphenyl-3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)acetamide (XN05), exhibited potent antitumor activity against various cancer cells in vitro. XN05-treatment in human ... Read more...

Latest indexed articles for 'Isoxazoles - Pharmacology'

These are the very latest articles for this heading:

• Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition. 6 Sep 2009
• Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells. 30 Aug 2009
• [Endothelin-receptor antagonists in therapy of pulmonary arterial hypertension] 26 Aug 2009
• XN05, a novel synthesized microtubule inhibitor, exhibits potent activity against human carcinoma cells in vitro. Aug 2009
• Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station. 30 Jul 2009
• The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line. 30 Jul 2009
• Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus. 30 Jul 2009
• Effects of essential fatty acid deficiency on enterohepatic circulation of bile salts in mice. 14 Jul 2009
• Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine. 13 Jul 2009
• Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges. 6 Jul 2009
• Synthesis of the isoxazolo[4,3,2-de]phenanthridinone moiety of the parnafungins. 30 Jun 2009
• Methodological aspects of measuring absolute values of membrane potential in human cells by flow cytometry. 29 Jun 2009
• FXR agonist activity of conformationally constrained analogs of GW 4064. 19 Jun 2009
• Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors. 19 Jun 2009
• Novel derivatives of ISO-1 as potent inhibitors of MIF biological function. 15 Jun 2009
• Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists". 7 Jun 2009
• Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1 receptor. 31 May 2009
• Synthesis and immunomodulation of human lymphocyte proliferation and cytokine (interferon-gamma) production of four novel malonitrilamides. 30 May 2009
• Parecoxib inhibits apoptosis in acute myocardial infarction due to permanent coronary ligation but not due to ischemia-reperfusion. 30 May 2009
• The effect of Malononitrilamides (FK778) on phenotypic properties of human peripheral dendritic cells. 30 May 2009

See a longer list of these articles.

Technical information about 'Isoxazoles'

Definition: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.

Chemical name: 1-Oxa-2-azacyclopentadiene

Registry Number: 0

Descriptor UI: D007555

Alternative terms: Isoxazoles;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.129.385;

Online Note: search OXAZOLES 1966-74

History Note: 91(75); was see under OXAZOLES 1975-90