Isoxazoles
Research News and Information

Monday, November 23, 2009

The influence of hepatic impairment on the pharmacokinetics of paliperidone.

29 Sep 2009 OBJECTIVES: This study assessed the impact of hepatic impairment on the pharmacokinetics (PK) of paliperidone and its enantiomers. METHODS: A single 1 mg dose of paliperidone immediate-release (IR) was administered to subjects with moderate hepatic ... Read more...

Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition.

6 Sep 2009 This investigation addressed the paradox that disintegrins and small RGD-ligands readily bind to the resting alphaIIbbeta3 integrin, while macromolecules with similar integrin recognition motifs require an activated, or primed, receptor. Three ... Read more...

Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles.

Sep 2009 A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with alpha,beta-unsaturated aldehydes/ketones. This novel strategy is ... Read more...

Latest indexed articles for 'Isoxazoles'

These are the very latest articles for this heading:

• The influence of hepatic impairment on the pharmacokinetics of paliperidone. 29 Sep 2009
• Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition. 6 Sep 2009
• Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles. Sep 2009
• Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells. 30 Aug 2009
• Efficacy and tolerability of zonisamide as add-on in brain tumor-related epilepsy: preliminary report. 30 Aug 2009
• The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent? 30 Aug 2009
• [Endothelin-receptor antagonists in therapy of pulmonary arterial hypertension] 26 Aug 2009
• Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis. Aug 2009
• XN05, a novel synthesized microtubule inhibitor, exhibits potent activity against human carcinoma cells in vitro. Aug 2009
• Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station. 30 Jul 2009
• Zonisamide: in Parkinson's disease. 30 Jul 2009
• Immunosuppressants: JC virus encephalopathy. Rare but fatal. 30 Jul 2009
• Leflunomide use in renal transplantation. 30 Jul 2009
• The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line. 30 Jul 2009
• Dihydroorotate dehydrogenase polymorphism influences the toxicity of leflunomide treatment in patients with rheumatoid arthritis. 30 Jul 2009
• Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus. 30 Jul 2009
• Effects of essential fatty acid deficiency on enterohepatic circulation of bile salts in mice. 14 Jul 2009
• Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine. 13 Jul 2009
• Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges. 6 Jul 2009
• The effects of paroxetine on the pharmacokinetics of paliperidone extended-release tablets. 5 Jul 2009

See a longer list of these articles.

Technical information about 'Isoxazoles'

Definition: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.

Chemical name: 1-Oxa-2-azacyclopentadiene

Registry Number: 0

Descriptor UI: D007555

Alternative terms: Isoxazoles;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.129.385;

Online Note: search OXAZOLES 1966-74

History Note: 91(75); was see under OXAZOLES 1975-90