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Ketone Bodies - Metabolism
Research News and Information
Definition of 'Ketone Bodies'The substances beta-hydroxybutyric acid, acetoacetic acid, and acetone, which are produced by fatty acid and carbohydrate metabolism in the liver in approximately a 78:20:2 ratio. Acetoacetate is produced from acetyl-CoA. Most is enzymatically converted to beta-ketobutyrate, but a small amount is spontaneously decarboxylated to acetone. The ketone bodies can be used as fuels by muscle and brain tissue. In starvation and uncontrolled diabetes mellitus, large quantities are produced, causing metabolic acidosis and elevated blood and urine levels of all three ketone bodies. (Dorland, 28th ed) |
Monday, November 23, 2009
GABA action in immature neocortical neurons directly depends on the availability of ketone bodies.
20 Jun 2009 
In the early postnatal period, energy metabolism in the suckling rodent brain relies to a large extent on metabolic pathways alternate to glucose such as the utilization of ketone bodies (KBs). However, how KBs affect neuronal excitability is not ... Read more...
Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation.
20 Jun 2009 
Studies in mice indicate that the gut microbiota promotes energy harvest and storage from components of the diet when these components are plentiful. Here we examine how the microbiota shapes host metabolic and physiologic adaptations to periods of ... Read more...
16 May 2009 Ketone bodies serve as alternative energy substrates for the brain in cases of low glucose availability such as during starvation or in patients treated with a ketogenic diet. The ketone bodies are metabolized via a distinct pathway confined to the ... Read more...
Latest indexed articles for 'Ketone Bodies - Metabolism'
These are the very latest articles for this heading:
- GABA action in immature neocortical neurons directly depends on the availability of ketone bodies. 20 Jun 2009
- Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation. 20 Jun 2009
- Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons. 16 May 2009
- The ketogenic diet has no effect on the expression of spike-and-wave discharges and nutrient transporters in genetic absence epilepsy rats from Strasbourg. 29 Apr 2009
- Rescue of Abeta(1-42)-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer's disease. 29 Apr 2009
- Metabolic response to a ketogenic breakfast in the healthy elderly. 30 Mar 2009
- Tolerance to fast: rational and practical evaluation in children with hypoketonaemia. 2 Mar 2009
- No change of body mass, fat mass, and skeletal muscle mass in ultraendurance swimmers after 12 hours of swimming. 27 Feb 2009
- Effects of insulin on ketogenesis following fasting in lean and obese men. 17 Feb 2009
- Impact of hyperketonemia in early lactation dairy cows on health and production. 30 Jan 2009
- Ketone bodies inhibit the viability of human neuroblastoma cells. 30 Dec 2008
- Plasma levels of PBEF/Nampt/visfatin are decreased in patients with liver cirrhosis. 10 Dec 2008
- Genetic obesity affects neural ketone body utilization in the rat brain. 9 Dec 2008
- Hypometabolism as a therapeutic target in Alzheimer's disease. Dec 2008
- [Ketogenic diets: additional benefits to the weight loss and unfounded secondary effects] 29 Nov 2008
- Ketone bodies, glycolysis, and KATP channels in the mechanism of the ketogenic diet. 30 Oct 2008
- Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets. 30 Oct 2008
- Assessing ketosis: approaches and pitfalls. 30 Oct 2008
- The ketogenic diet in children with Glut1 deficiency syndrome and epilepsy. 30 Oct 2008
- Ketone body utilization is regulated by male-specific factors in rat subcutaneous adipocytes. 29 Sep 2008
See a longer list of these articles.
Technical information about 'Ketone Bodies'
Definition: The substances beta-hydroxybutyric acid, acetoacetic acid, and acetone, which are produced by fatty acid and carbohydrate metabolism in the liver in approximately a 78:20:2 ratio. Acetoacetate is produced from acetyl-CoA. Most is enzymatically converted to beta-ketobutyrate, but a small amount is spontaneously decarboxylated to acetone. The ketone bodies can be used as fuels by muscle and brain tissue. In starvation and uncontrolled diabetes mellitus, large quantities are produced, causing metabolic acidosis and elevated blood and urine levels of all three ketone bodies. (Dorland, 28th ed)
Registry Number: 0
Descriptor UI: D007657
Alternative terms: Ketone Bodies; Bodies, Ketone; Acetone Bodies; Bodies, Acetone;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; biosynthesis;
Tree Number: D02.522.585;
Technical Notes: acetonemia, acetonuria, ketonemia & ketonuria go here; ketogenesis is probably KETONE BODIES /biosyn