Kinins
Research News and Information

Tuesday, February 09, 2010

Cross talk between kinin and angiotensin II receptors in mouse abdominal aorta.

30 Aug 2009 Bradykinin (BK) is a vasorelaxant, algesic and inflammatory agent. Angiotensin II (AngII) is known to control vascular tone and promote growth, inflammation and artherogenesis. There is evidence for cross talking between BK and AngII receptors. ... Read more...

Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.

15 Aug 2009 Porphyromonas gingivalis, a Gram-negative bacterium that causes periodontitis, activates the kinin system via the cysteine protease R-gingipain. Using a model of buccal infection based on P. gingivalis inoculation in the anterior mandibular ... Read more...

Kallikrein-kinin system and fibrinolysis in hereditary angioedema due to factor XII gene mutation Thr309Lys.

29 Jun 2009 In a subgroup of hereditary angioedema (HAE) patients with normal C1-esterase inhibitor levels, HAE is caused by a Thr309Lys mutation in the coagulation factor XII (F12) gene. The aim of this study was to examine elements of the kallikrein-kinin ... Read more...

Latest indexed articles for 'Kinins'

These are the very latest articles for this heading:

• Cross talk between kinin and angiotensin II receptors in mouse abdominal aorta. 30 Aug 2009
• Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis. 15 Aug 2009
• Kallikrein-kinin system and fibrinolysis in hereditary angioedema due to factor XII gene mutation Thr309Lys. 29 Jun 2009
• Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin. 13 Jun 2009
• Physiological responses to protein aggregates: fibrinolysis, coagulation and inflammation (new roles for old factors). 11 Jun 2009
• The contact/kinin and complement systems in vasculitis. 30 May 2009
• Toward the development of novel pest management agents based upon insect kinin neuropeptide analogues. 30 Mar 2009
• Proteolytic generation of kinins in tissues infected by Trypanosoma cruzi depends on CXC chemokine secretion by macrophages activated via Toll-like 2 receptors. 15 Mar 2009
• Expression of the kallikrein/kinin system in human anterior segment. 2 Mar 2009
• [Hereditary angioedema: a case series and bibliographic update] 27 Feb 2009
• Kallikreins, kininogens and kinin receptors on circulating and synovial fluid neutrophils: role in kinin generation in rheumatoid arthritis. 27 Feb 2009
• The assembly and activation of kinin-forming systems on the surface of human U-937 macrophage-like cells. 27 Feb 2009
• Tissue kallikrein deficiency and renovascular hypertension in the mouse. 23 Feb 2009
• Signaling to the apical membrane and to the paracellular pathway: changes in the cytosolic proteome of Aedes Malpighian tubules. 30 Jan 2009
• Plasma kallikrein mediates angiotensin II type 1 receptor-stimulated retinal vascular permeability. 3 Jan 2009
• Multifunctional drugs for head injury. 30 Dec 2008
• Novel perspectives of neural stem cell differentiation: from neurotransmitters to therapeutics. 30 Dec 2008
• S(1)' and S(2)' subsite specificities of human plasma kallikrein and tissue kallikrein 1 for the hydrolysis of peptides derived from the bradykinin domain of human kininogen. 29 Nov 2008
• Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects. 24 Nov 2008
• Biostable agonists that match or exceed activity of native insect kinins on recombinant arthropod GPCRs. 17 Oct 2008

See a longer list of these articles.

Technical information about 'Kinins'

Definition: A generic term used to describe a group of polypeptides with related chemical structures and pharmacological properties that are widely distributed in nature. These peptides are AUTACOIDS that act locally to produce pain, vasodilatation, increased vascular permeability, and the synthesis of prostaglandins. Thus, they comprise a subset of the large number of mediators that contribute to the inflammatory response. (From Goodman and Gilman's The Pharmacologic Basis of Therapeutics, 8th ed, p588)

Registry Number: 0

Descriptor UI: D007705

Alternative terms: Kinins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.812; D12.776.467.812; D23.469.050.375; D23.529.812;

History Note: 66(64)

Technical Notes: a group of polypeptide autacoids