Kruppel-Like Transcription Factors - Genetics
Research News and Information

Monday, November 23, 2009

KLF family members regulate intrinsic axon regeneration ability.

7 Oct 2009 Neurons in the central nervous system (CNS) lose their ability to regenerate early in development, but the underlying mechanisms are unknown. By screening genes developmentally regulated in retinal ganglion cells (RGCs), we identified Krüppel-like ... Read more...

The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells.

29 Sep 2009 The potential for clinical application of pluripotent embryonic stem cells is immense but hampered by moral and ethical complications. Recent advances in the reprogramming of somatic cells by defined factors to a state that resemble embryonic stem ... Read more...

Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb.

29 Sep 2009 The vertebrate hedgehog receptor patched 1 (Ptc1) is crucial for negative regulation of the sonic hedgehog (Shh) pathway during anterior-posterior patterning of the limb. We have conditionally inactivated Ptc1 in the mesenchyme of the mouse limb ... Read more...

Latest indexed articles for 'Kruppel-Like Transcription Factors - Genetics'

These are the very latest articles for this heading:

• KLF family members regulate intrinsic axon regeneration ability. 7 Oct 2009
• Neuroscience. Nuclear power for axonal growth. 7 Oct 2009
• Human genetics: Hit or miss? 6 Oct 2009
• The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells. 29 Sep 2009
• Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. 29 Sep 2009
• Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome. 29 Sep 2009
• Posttranslational regulation of Myc by promyelocytic leukemia zinc finger protein. 29 Sep 2009
• On the road to iPS cell cardiovascular applications. 23 Sep 2009
• C-terminal binding proteins (CtBPs) attenuate KLF4-mediated transcriptional activation. 10 Sep 2009
• Activation of sonic hedgehog signaling pathway in olfactory neuroblastoma. 5 Sep 2009
• Transgenic mice expressing constitutively active Akt in oral epithelium validate KLFA as a potential biomarker of head and neck squamous cell carcinoma. 30 Aug 2009
• The role of PLZF in human myeloid development. 30 Aug 2009
• Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation? 30 Aug 2009
• Dual and opposing roles of primary cilia in medulloblastoma development. 21 Aug 2009
• iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. 18 Aug 2009
• KAP1-independent transcriptional repression of SCAN-KRAB-containing zinc finger proteins. 16 Aug 2009
• Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of transforming growth factor beta. 12 Aug 2009
• Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1. 8 Aug 2009
• The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms. 8 Aug 2009
• Proteasome inhibitors enhance endothelial thrombomodulin expression via induction of Krüppel-like transcription factors. 4 Aug 2009

See a longer list of these articles.

Technical information about 'Kruppel-Like Transcription Factors'

Definition: A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.

Registry Number: 0

Descriptor UI: D051741

Alternative terms: Kruppel-Like Transcription Factors; Kruppel Like Transcription Factors; Transcription Factors, Kruppel-Like; Kruppel-Like Factors; Kruppel Like Factors;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.260.522; D12.776.930.375;

History Note: 2006(1989)