Kruppel-Like Transcription Factors
Research News and Information

Sunday, November 22, 2009

Krüppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression.

13 Oct 2009 Gastric cancer is the second common malignant neoplasia in Japan, and its poorly differentiated form is a deadly disease. To identify novel candidate oncogenes contributing to its genesis, we examined copy-number alterations in 50 primary poorly ... Read more...

KLF family members regulate intrinsic axon regeneration ability.

7 Oct 2009 Neurons in the central nervous system (CNS) lose their ability to regenerate early in development, but the underlying mechanisms are unknown. By screening genes developmentally regulated in retinal ganglion cells (RGCs), we identified Krüppel-like ... Read more...

Tail wags dog: primary cilia and tumorigenesis.

4 Oct 2009 Aberrant activation of the Hedgehog (Hh) signaling pathway contributes to many forms of cancer. Primary cilia are Hh signal transduction centers. Two papers in a recent issue of Nature Medicine (Han et al., 2009; Wong et al., 2009) show that ... Read more...

Latest indexed articles for 'Kruppel-Like Transcription Factors'

These are the very latest articles for this heading:

• Krüppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression. 13 Oct 2009
• KLF family members regulate intrinsic axon regeneration ability. 7 Oct 2009
• Neuroscience. Nuclear power for axonal growth. 7 Oct 2009
• Human genetics: Hit or miss? 6 Oct 2009
• Tail wags dog: primary cilia and tumorigenesis. 4 Oct 2009
• The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells. 29 Sep 2009
• Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. 29 Sep 2009
• Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome. 29 Sep 2009
• Global and gene-specific promoter methylation changes are related to anti-B[a]PDE-DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon-exposed individuals. 29 Sep 2009
• Posttranslational regulation of Myc by promyelocytic leukemia zinc finger protein. 29 Sep 2009
• On the road to iPS cell cardiovascular applications. 23 Sep 2009
• C-terminal binding proteins (CtBPs) attenuate KLF4-mediated transcriptional activation. 10 Sep 2009
• The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. 9 Sep 2009
• Activation of sonic hedgehog signaling pathway in olfactory neuroblastoma. 5 Sep 2009
• Transgenic mice expressing constitutively active Akt in oral epithelium validate KLFA as a potential biomarker of head and neck squamous cell carcinoma. 30 Aug 2009
• The role of PLZF in human myeloid development. 30 Aug 2009
• KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57(Kip2). 30 Aug 2009
• Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation? 30 Aug 2009
• MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes. 27 Aug 2009
• Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases. 27 Aug 2009

See a longer list of these articles.

Technical information about 'Kruppel-Like Transcription Factors'

Definition: A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.

Registry Number: 0

Descriptor UI: D051741

Alternative terms: Kruppel-Like Transcription Factors; Kruppel Like Transcription Factors; Transcription Factors, Kruppel-Like; Kruppel-Like Factors; Kruppel Like Factors;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.260.522; D12.776.930.375;

History Note: 2006(1989)