L-Lactate Dehydrogenase - Metabolism
Research News and Information

Sunday, November 22, 2009

Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation.

30 Oct 2009 BACKGROUND: Aquaporin 4 (AQP4) plays a key role in maintaining water balance in the central nervous system, and its dysfunction may lead to brain edema. Previous studies have suggested that propofol may be involved in neuroprotection by preventing ... Read more...

Endothelial protein C receptor is expressed in rat cortical and hippocampal neurons and is necessary for protective effect of activated protein C at glutamate excitotoxicity.

23 Sep 2009 Activated protein C (APC) is an anticoagulant and anti-inflammatory factor that acts via endothelial protein C receptor (EPCR). Interestingly, APC also exhibits neuroprotective activities. In the present study, we demonstrate for the first time ... Read more...

Influence of calcium phosphate crystal morphology on the adhesion, spreading, and growth of bone derived cells.

13 Sep 2009 In this study, rat periosteal cells and bone marrow stromal cells (BMSC) were examined when cultured on octacalcium phosphate (OCP) crystals to determine the effects of crystal morphology on their adhesion, spreading, and growth. Three type of OCP ... Read more...

Latest indexed articles for 'L-Lactate Dehydrogenase - Metabolism'

These are the very latest articles for this heading:

• Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation. 30 Oct 2009
• Endothelial protein C receptor is expressed in rat cortical and hippocampal neurons and is necessary for protective effect of activated protein C at glutamate excitotoxicity. 23 Sep 2009
• Influence of calcium phosphate crystal morphology on the adhesion, spreading, and growth of bone derived cells. 13 Sep 2009
• Comparative characterization of a temperature responsive gene (lactate dehydrogenase-B, ldh-b) in two congeneric tropical fish, Lates calcarifer and Lates niloticus. 30 Aug 2009
• Efficient production of L-lactic acid by Crabtree-negative yeast Candida boidinii. 30 Aug 2009
• Ice nucleation temperature influences recovery of activity of a model protein after freeze drying. 30 Aug 2009
• Association of neonatal hypoxia with lasting changes in left ventricular gene expression: an animal model. 30 Aug 2009
• Oxalate-induced activation of PKC-alpha and -delta regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells. 17 Aug 2009
• Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. 12 Aug 2009
• Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth. 8 Aug 2009
• Comparative pulmonary toxicity study of nano-TiO(2) particles of different sizes and agglomerations in rats: different short- and long-term post-instillation results. 6 Aug 2009
• Mid-trimester amniotic fluid C-reactive protein, ferritin and lactate dehydrogenase concentrations and subsequent risk of spontaneous preterm labour. 30 Jul 2009
• Toxicity and bioaccumulation of the insecticide "Raid" in Wister rats. 30 Jul 2009
• Roots of Daphne gnidium L. inhibit cell proliferation and induce apoptosis in the human breast cancer cell line MCF-7. 30 Jul 2009
• Mesenchymal stem cells enhance the viability and proliferation of human fetal intestinal epithelial cells following hypoxic injury via paracrine mechanisms. 30 Jul 2009
• Acute postischemic treatment with estrogen receptor-alpha agonist or estrogen receptor-beta agonist improves myocardial recovery. 30 Jul 2009
• Enzymatic transition states and dynamic motion in barrier crossing. 30 Jul 2009
• Protective effects of caspase-9 and poly(ADP-ribose) polymerase inhibitors on ischemia-reperfusion-induced myocardial injury. 29 Jul 2009
• Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. 16 Jul 2009
• Enhanced dopaminergic differentiation of human neural stem cells by synergistic effect of Bcl-xL and reduced oxygen tension. 15 Jul 2009

See a longer list of these articles.

Technical information about 'L-Lactate Dehydrogenase'

Definition: A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.

Chemical name: (S)-Lactate:NAD+ oxidoreductase

Registry Number: EC 1.1.1.27

Descriptor UI: D007770

Alternative terms: L-Lactate Dehydrogenase; Dehydrogenase, L-Lactate; L Lactate Dehydrogenase; Lactate Dehydrogenase; Dehydrogenase, Lactate;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.682.047.551.400;

History Note: 2004(1966)