Learning Disorders - Genetics
Research News and Information

Saturday, November 21, 2009

Aberrant expression of synaptic plasticity-related genes in the NF1+/- mouse hippocampus.

30 Oct 2009 Neurofibromatosis 1 (NF1) is a common single-gene disorder that causes learning impairments in patients. Neurofibromin encoded by the NF1 causal gene regulates Ras/MAPK and cAMP signaling pathways. These signaling pathways play critical roles in ... Read more...

The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation.

25 Aug 2009 FE65 is expressed predominantly in the brain and interacts with the C-terminal domain of beta-amyloid precursor protein (APP). We examined hippocampus-dependent memory and in vivo long-term potentiation (LTP) at the CA1 synapses with ... Read more...

Role of dentate gyrus in aligning internal spatial map to external landmark.

23 Aug 2009 Humans and animals form internal representations of external space based on their own body movement (dead reckoning) as well as external landmarks. It is poorly understood, however, how different types of information are integrated to form a unified ... Read more...

Latest indexed articles for 'Learning Disorders - Genetics'

These are the very latest articles for this heading:

• Aberrant expression of synaptic plasticity-related genes in the NF1+/- mouse hippocampus. 30 Oct 2009
• The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation. 25 Aug 2009
• Role of dentate gyrus in aligning internal spatial map to external landmark. 23 Aug 2009
• Krüppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis. 3 Aug 2009
• A novel mitochondrial DNA mutation in COX1 leads to strokes, seizures, and lactic acidosis. 28 Jun 2009
• Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice. 6 Jun 2009
• Impairments in fear conditioning in mice lacking the nNOS gene. 21 May 2009
• Apolipoprotein E modulates auditory event-related potentials in healthy aging. 2 May 2009
• Does the learning deficit observed under an incremental repeated acquisition schedule of reinforcement in Ts65Dn mice, a model for Down syndrome, change as they age? May 2009
• Brain magnetic resonance imaging of siblings from families with two or more children with learning or intellectual disabilities and need for full-time special education. 29 Apr 2009
• Two children with subtelomeric 11q deletions: a description and interpretation of their clinical presentations and molecular genetic findings. 30 Mar 2009
• Subtle but progressive cognitive deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance. 26 Mar 2009
• Impairment of novelty detection in mice targeted for the Chl1 gene. 16 Mar 2009
• A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory. 23 Feb 2009
• Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. 16 Feb 2009
• RNF135 mutations are not present in patients with Sotos syndrome-like features. 13 Feb 2009
• Learning abilities and disabilities: generalist genes in early adolescence. 30 Dec 2008
• Potential influences on mathematical difficulties in children and adolescents with neurofibromatosis, type 1. 30 Dec 2008
• Mathematical learning disabilities in children with 22q11.2 deletion syndrome: a review. 30 Dec 2008
• Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. 29 Dec 2008

See a longer list of these articles.

Technical information about 'Learning Disorders'

Definition: Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These disorders may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, dyscalculia, and dysgraphia.

Descriptor UI: D007859

Alternative terms: Learning Disorders; Learning Disorder; Learning Disturbance; Disturbance, Learning; Disturbances, Learning; Learning Disturbances; Adult Learning Disorders; Adult Learning Disorder; Learning Disorder, Adult; Learning Disorders, Adult; Developmental Academic Disorder; Academic Disorders, Developmental; Developmental Academic Disorders; Developmental Disorders of Scholastic Skills; Academic Disorder, Developmental; Scholastic Skills Development Disorders; Learning Disabilities; Disabilities, Learning; Disability, Learning; Learning Disability;

Related Mesh Headings: Dyslexia;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; diagnosis; diet therapy; drug therapy; economics; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; rehabilitation; surgery; therapy; urine; ultrasonography; virology;

Tree Number: C10.597.606.150.550; C23.888.592.604.150.550; F03.550.350.500; F03.550.450;

History Note: 1966(1964)