Lentivirus
Research News and Information

Monday, November 23, 2009

Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain.

5 Oct 2009 BACKGROUND: Lentiviral vectors are well suited for gene therapy because they can mediate long-term expression in both dividing and nondividing cells. However, lentiviral vectors seem less suitable for liver gene therapy because systemically ... Read more...

Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis.

3 Oct 2009 The Tim (Timeless)-Tipin complex has been proposed to maintain genome stability by facilitating ATR-mediated Chk1 activation. However, as a replisome component, Tim-Tipin has also been suggested to couple DNA unwinding to synthesis, an activity ... Read more...

Lentivirus production.

30 Sep 2009 RNA interference (RNAi) is a system of gene silencing in living cells. In RNAi, genes homologous in sequence to short interfering RNAs (siRNA) are silenced at the post-transcriptional state. Short hairpin RNAs, precursors to siRNA, can be expressed ... Read more...

Latest indexed articles for 'Lentivirus'

These are the very latest articles for this heading:

• Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain. 5 Oct 2009
• Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. 3 Oct 2009
• Lentivirus production. 30 Sep 2009
• CXCR4 enhances engraftment of muscle progenitor cells. 29 Sep 2009
• The prion or the related Shadoo protein is required for early mouse embryogenesis. 16 Sep 2009
• Targeting of prostate cancer cells by a cytotoxic lentiviral vector containing a prostate stem cell antigen (PSCA) promoter. 13 Sep 2009
• Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. 8 Sep 2009
• Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO. 6 Sep 2009
• Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2. Sep 2009
• Lentiviral calnexin-modified dendritic cells promote expansion of high-avidity effector T cells with central memory phenotype. 30 Aug 2009
• Introduction of a foreign gene into zebrafish and medaka cells using adenoviral vectors. 30 Aug 2009
• A dual role of the N-terminal FQQI motif in GLUT4 trafficking. 30 Aug 2009
• Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells. 30 Aug 2009
• Tumors originating from induced pluripotent stem cells and methods for their prevention. 30 Aug 2009
• Ethyl pyruvate administration inhibits hepatic tumor growth. 30 Aug 2009
• An uphill battle toward pluripotency. 30 Aug 2009
• Genetic modification of T cells with IL-21 enhances antigen presentation and generation of central memory tumor-specific cytotoxic T-lymphocytes. 30 Aug 2009
• Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy. 18 Aug 2009
• Characterization of Chikungunya pseudotyped viruses: Identification of refractory cell lines and demonstration of cellular tropism differences mediated by mutations in E1 glycoprotein. 16 Aug 2009
• Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons. 15 Aug 2009

See a longer list of these articles.

Technical information about 'Lentivirus'

Definition: A genus of the family RETROVIRIDAE consisting of non-oncogenic retroviruses that produce multi-organ diseases characterized by long incubation periods and persistent infection. Lentiviruses are unique in that they contain open reading frames (ORFs) between the pol and env genes and in the 3' env region. Five serogroups are recognized, reflecting the mammalian hosts with which they are associated. HIV-1 is the type species.

Descriptor UI: D016086

Alternative terms: Lentivirus; Lentiviruses; Lentivirinae;

Allowable Qualifiers: classification; drug effects; enzymology; genetics; growth & development; immunology; isolation & purification; metabolism; pathogenicity; physiology; radiation effects; ultrastructure; chemistry;

Tree Number: B04.820.650.589; B04.909.777.731.589;

Online Note: use LENTIVIRUS to search LENTIVIRINAE 1991-93

History Note: 94; was LENTIVIRINAE 1991-93

Technical Notes: a genus of the family Retroviridae; Latin lenti-, slow, refers to its long incubation period; infection = LENTIVIRUS INFECTIONS