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Leptin - Blood
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Definition of 'Leptin'

A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.

Common names: Leptin; Obese Protein; Obese Gene Product; Gene Product, Obese; Ob Gene Product; Gene Product, Ob; Ob Protein

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Monday, November 23, 2009

A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss.

29 Sep 2009 Post-menopausal osteoporosis is considered to be an inflammatory process, in which numerous pro-inflammatory and T-cell-derived cytokines play a bone-destructive role. IL-17A is the signature cytokine of the pro-inflammatory Th17 population and ... Read more...


A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload.

16 Sep 2009 A high-fat diet can increase adiposity, leptin secretion, and plasma fatty acid concentration. In hypertension, this scenario may accelerate cardiac hypertrophy and development of heart failure but could be protective by activating peroxisome ... Read more...


Adiponectin is a mediator of the inverse association of adiposity with radiographic damage in rheumatoid arthritis.

13 Sep 2009 OBJECTIVE: Recent reports have suggested that increasing adiposity may protect against radiographic damage in rheumatoid arthritis (RA). We explored the role of serum adipokines (adiponectin, resistin, and leptin) in mediating this association. ... Read more...

 

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Technical information about 'Leptin'

Definition: A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.

Registry Number: 0

Descriptor UI: D020738

Alternative terms: Leptin; Obese Protein; Obese Gene Product; Gene Product, Obese; Ob Gene Product; Gene Product, Ob; Ob Protein;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D06.472.699.042.500; D12.644.276.024.500; D12.644.548.011.500; D12.776.467.024.500; D23.529.024.500;

History Note: 2000; use LEPTIN (NM) 1995-1999

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