Leptin
Research News and Information

Sunday, November 22, 2009

Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells.

30 Oct 2009 Cardiomyocyte apoptosis is a component of cardiac remodeling that can contribute to heart failure in obesity. A role for leptin in mediating this process has been suggested and the objective of this work was to investigate the effect of leptin on ... Read more...

Glucocorticoid regulation of the circadian clock modulates glucose homeostasis.

3 Oct 2009 Circadian clock genes are regulated by glucocorticoids; however, whether this regulation is a direct or secondary effect and the physiological consequences of this regulation were unknown. Here, we identified glucocorticoid response elements (GREs) ... Read more...

A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss.

29 Sep 2009 Post-menopausal osteoporosis is considered to be an inflammatory process, in which numerous pro-inflammatory and T-cell-derived cytokines play a bone-destructive role. IL-17A is the signature cytokine of the pro-inflammatory Th17 population and ... Read more...

Latest indexed articles for 'Leptin'

These are the very latest articles for this heading:

• Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. 30 Oct 2009
• Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. 3 Oct 2009
• A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss. 29 Sep 2009
• Impact of micronutrient deficiencies on obesity. 29 Sep 2009
• Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells. 29 Sep 2009
• Genetic association study of selected candidate genes (ApoB, LPL, Leptin) and telomere length in obese and hypertensive individuals. 20 Sep 2009
• Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus. 19 Sep 2009
• A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload. 16 Sep 2009
• Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. 14 Sep 2009
• Adiponectin is a mediator of the inverse association of adiposity with radiographic damage in rheumatoid arthritis. 13 Sep 2009
• Low-birth weight children develop lower sex hormone binding globulin and higher dehydroepiandrosterone sulfate levels and aggravate their visceral adiposity and hypoadiponectinemia between six and eight years of age. 6 Sep 2009
• A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. 2 Sep 2009
• Neural and hormonal regulation of pancreatic secretion. 30 Aug 2009
• Reduced fat oxidation and obesity risks among the Buryat of Southern Siberia. 30 Aug 2009
• Postnatal stress produces hyperglycemia in adult rats exposed to hypoxia-ischemia. 30 Aug 2009
• Influence of Helicobacter pylori on gastric regulation of food intake. 30 Aug 2009
• An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. 30 Aug 2009
• The role of key adipokines in obesity and insulin resistance in cats. 30 Aug 2009
• Mouse fertility is not dependent on the CREB coactivator Crtc1. 30 Aug 2009
• Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Leptin'

Definition: A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.

Registry Number: 0

Descriptor UI: D020738

Alternative terms: Leptin; Obese Protein; Obese Gene Product; Gene Product, Obese; Ob Gene Product; Gene Product, Ob; Ob Protein;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D06.472.699.042.500; D12.644.276.024.500; D12.644.548.011.500; D12.776.467.024.500; D23.529.024.500;

History Note: 2000; use LEPTIN (NM) 1995-1999