Lethal Dose 50
Research News and Information

Sunday, November 22, 2009

Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice.

6 Sep 2009 Expressed in liver, aquaglyceroporin-9 (AQP9) is permeated by glycerol, arsenite, and other small, neutral solutes. To evaluate a possible protective role, AQP9-null mice were evaluated for in vivo arsenic toxicity. After injection with NaAsO(2), ... Read more...

Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized rats.

24 Aug 2009 Soy isoflavones and their metabolites, with estrogenic activity, have been considered candidates for reducing postmenopausal bone loss. In this study, we examined the effect of dietary equol, a bioactive metabolite of the soy isoflavone daidzein, on ... Read more...

Inhalation exposure to sulfur mustard in the guinea pig model: clinical, biochemical and histopathological characterization of respiratory injuries.

10 Aug 2009 Guinea pigs (GP) were exposed (head only) in individual plethysmographs to various concentrations of sulfur mustard vapor, determined online, using FTIR attached to flow chamber. The LCt(50) and the inhaled LD(50) were calculated at different time ... Read more...

Latest indexed articles for 'Lethal Dose 50'

These are the very latest articles for this heading:

• Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice. 6 Sep 2009
• Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized rats. 24 Aug 2009
• Inhalation exposure to sulfur mustard in the guinea pig model: clinical, biochemical and histopathological characterization of respiratory injuries. 10 Aug 2009
• Determination of LC(50) of permethrin acaricide in semi-engorged females of the tick Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae). 9 Aug 2009
• Mortality and abnormalities observed after experimental Hg exposure in the polychaete Eurythoe complanata (Pallas) from Mazatlan, Mexico. 3 Aug 2009
• Mosquitocidal activities of thyme oils (Thymus vulgaris L.) against Culex quinquefasciatus (Diptera: Culicidae). 2 Aug 2009
• The expression of a recombinant cry1Ac gene with subtilisin-like protease CDEP2 gene in acrystalliferous Bacillus thuringiensis by Red/ET homologous recombination. 2 Aug 2009
• Molluscicidal activity of Piper cubeba Linn., Piper longum Linn. and Tribulus terrestris Linn. and their combinations against snail Indoplanorbis exustus Desh. 30 Jul 2009
• Larvicidal activities of three plants against filarial vector Culex quinquefasciatus Say (Diptera: Culicidae). 29 Jul 2009
• Virulence increasing of Salmonella typhimurium in Balb/c mice after heat-stress induction of phage shock protein A. 26 Jul 2009
• Isolation and chimerization of a highly neutralizing antibody conferring passive protection against lethal Bacillus anthracis infection. 22 Jul 2009
• Effects of temperature on the sensitivity of Gammarus aequicauda (Martynov, 1931) to cadmium. 22 Jul 2009
• Burkholderia pseudomallei isocitrate lyase is a persistence factor in pulmonary melioidosis: implications for the development of isocitrate lyase inhibitors as novel antimicrobials. 18 Jul 2009
• Tentative identification of glycerol dehydrogenase as Escherichia coli K1 virulence factor cglD and its involvement in the pathogenesis of experimental neonatal meningitis. 12 Jul 2009
• Modified Bacillus thuringiensis toxins and a hybrid B. thuringiensis strain counter greenhouse-selected resistance in Trichoplusia ni. 8 Jul 2009
• Mosquito larvicidal activities of extractives from black heartwood-type Cryptomeria japonica. Jul 2009
• [Influence of mutation L,D-carboxypeptidase-coding gene on dynamics of Listeria infection] 29 Jun 2009
• Experimental conditions substantially influence botulinum toxin potency testing. 29 Jun 2009
• Involvement of Fas/FasL system in apoptotic signaling in testicular germ cells of male Wistar rats injected i.v. with microcystins. 29 Jun 2009
• Food protective effect of geraniol and its congeners against stored food mites. 29 Jun 2009

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Technical information about 'Lethal Dose 50'

Definition: The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

Descriptor UI: D007928

Alternative terms: Lethal Dose 50; Dose 50, Lethal; LD50;

Tree Number: E05.940.402; G07.690.520;

History Note: 76(71); was see under TOXICOLOGY 1975

Technical Notes: almost never IM; do not coord with /mortal in exper studies; DF: LD 50 or LD50