Lignans - Pharmacology
Research News and Information

Sunday, November 22, 2009

Inhibitory effects of honokiol on LPS and PMA-induced cellular responses of macrophages and monocytes.

28 Sep 2009 The regulatory effects of honokiol on the cellular responses of macrophages and monocytes were evaluated. Specifically, we investigated the effects of honokiol with respect to lipopolysaccharide (LPS)-induced cytotoxicity, LPS- or ... Read more...

Combined administration of the mixture of honokiol and magnolol and ginger oil evokes antidepressant-like synergism in rats.

24 Sep 2009 Magnolia bark combined with ginger rhizome is a common drug pair in traditional Chinese prescriptions for the treatment of depression. In the present study, we examined antidepressant-like effects of the mixture of honokiol and magnolol (HMM) from ... Read more...

Nitric oxide scavenging lignans from Vitex negundo seeds.

30 Aug 2009 A new phenyldihydronaphthalene-type lignan, vitexdoin A (1), a new phenylnaphthalene-type lignan alkaloid, vitedoamine B (2), four new phenylnaphthalene-type lignans, vitexdoins B-E (3-6), and four known lignan derivatives (7-10) were isolated from ... Read more...

Latest indexed articles for 'Lignans - Pharmacology'

These are the very latest articles for this heading:

• Inhibitory effects of honokiol on LPS and PMA-induced cellular responses of macrophages and monocytes. 28 Sep 2009
• Combined administration of the mixture of honokiol and magnolol and ginger oil evokes antidepressant-like synergism in rats. 24 Sep 2009
• Nitric oxide scavenging lignans from Vitex negundo seeds. 30 Aug 2009
• Oxygenated lignans from the fruits of Schisandra arisanensis. 30 Aug 2009
• PAF-antagonistic bicyclo[3.2.1]octanoid neolignans from leaves of Ocotea macrophylla Kunth. (Lauraceae). 8 Aug 2009
• Constituents of the leaves of Magnolia ovata. 30 Jul 2009
• Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice. 30 Jul 2009
• Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line. 29 Jun 2009
• Anti-clastogenic effect of magnolol-containing Hange-koboku-to, Dai-joki-to, Goshaku-san, and Magnoliae Cortex on benzo(a)pyrene-induced clastogenicity in mice. 29 Jun 2009
• Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. 29 Jun 2009
• Phenylethanoid and lignan glycosides from polar extracts of Lantana, a genus of verbenaceous plants widely used in traditional herbal therapies. 29 Jun 2009
• Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function. 29 Jun 2009
• Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity. 29 Jun 2009
• Cytoprotective effect of lignans from Forsythia suspensa against peroxynitrite-induced LLC-PK1 cell damage. 29 Jun 2009
• Inhibitory effect of magnolol on Trp-P-2-induced DNA damage in various organs in mice. 29 Jun 2009
• Glycosides of arylnaphthalene lignans from Acanthus mollis having axial chirality. 22 Jun 2009
• Semi-synthesis and anti-proliferative activity evaluation of novel analogues of Honokiol. 19 Jun 2009
• Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway. 14 Jun 2009
• A novel and efficient synthesis of highly oxidized lignans by a methyltrioxorhenium/hydrogen peroxide catalytic system. Studies on their apoptogenic and antioxidant activity. 11 Jun 2009
• Meta-analysis of the effects of flaxseed interventions on blood lipids. 8 Jun 2009

See a longer list of these articles.

Technical information about 'Lignans'

Definition: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Registry Number: 0

Descriptor UI: D017705

Alternative terms: Lignans; Neolignans;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; biosynthesis;

Tree Number: D02.455.426.559.389.140.450;

Online Note: use LIGNANS (NM) to search LIGNANS 1980-93

History Note: 94; was LIGNANS (NM) 1979-93

Technical Notes: do not confuse with LIGNIN, also found in plants