Lipodystrophy, Familial Partial
Research News and Information

Sunday, November 22, 2009

Lipodystrophy: an unusual diagnosis in a case of oligomenorrhea and hirsutism.

30 Jul 2009 BACKGROUND: Familial partial lipodystrophy, Dunnigan variety, is a rare autosomal dominant disorder caused by missense mutations in LMNA gene. Individuals are predisposed to insulin resistance and its complications, including features of polycystic ... Read more...

Structure of the lamin A/C R482W mutant responsible for dominant familial partial lipodystrophy (FPLD).

25 Jun 2009 Proteins of the A-type lamin family, which consists of two members, lamin A and lamin C, are the major components of a thin proteinaceous filamentous meshwork, the lamina, that underlies the inner nuclear membrane. A-type lamins have recently become ... Read more...

Predicting abdominal adipose tissue among women with familial partial lipodystrophy.

30 May 2009 The objective of the study was to determine correlations between magnetic resonance imaging (MRI) measures of truncal adiposity (trunk fat percentage [TrF %(MRI)], visceral adipose tissue [VAT], and subcutaneous abdominal adipose tissue [SAT]), ... Read more...

Latest indexed articles for 'Lipodystrophy, Familial Partial'

These are the very latest articles for this heading:

• Lipodystrophy: an unusual diagnosis in a case of oligomenorrhea and hirsutism. 30 Jul 2009
• Structure of the lamin A/C R482W mutant responsible for dominant familial partial lipodystrophy (FPLD). 25 Jun 2009
• Predicting abdominal adipose tissue among women with familial partial lipodystrophy. 30 May 2009
• Serum retinol binding protein 4 in patients with familial partial lipodystrophy. 16 Mar 2009
• Long-term improvement of metabolic control with pioglitazone in a woman with diabetes mellitus related to Dunnigan syndrome: a case report. 24 Feb 2009
• The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress. 9 Feb 2009
• Comparison of phenotypes in male and female individuals of a new family with Dunnigan type of familial partial lipodystrophy due to a lamin A/C R482W mutation. 7 Feb 2009
• The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation. 3 Feb 2009
• Lipodystrophies: disorders of adipose tissue biology. 5 Jan 2009
• Prolonged thiazolidinedione therapy does not reverse fat loss in patients with familial partial lipodystrophy, Dunnigan variety. 29 Nov 2008
• Prevalence of reproductive abnormalities among women with familial partial lipodystrophy. 29 Nov 2008
• A case of Dunnigan-type familial partial lipodystrophy (FPLD) due to lamin A/C (LMNA) mutations complicated by end-stage renal disease. 13 Nov 2008
• Severe acanthosis nigricans in a 17 year-old female with partial lipodystrophic syndrome. 30 Oct 2008
• Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy. Oct 2008
• Site-dependent differences in both prelamin A and adipogenic genes in subcutaneous adipose tissue of patients with type 2 familial partial lipodystrophy. 17 Sep 2008
• Fatty acid metabolism in patients with PPARgamma mutations. 17 Aug 2008
• [Partial lipodystrophy and POEMS syndrome: a case report] 22 Jul 2008
• A novel phenotypic expression associated with a new mutation in LMNA gene, characterized by partial lipodystrophy, insulin resistance, aortic stenosis and hypertrophic cardiomyopathy. 29 Jun 2008
• Genetics of metabolic syndrome: is there a role for phenomics? 30 May 2008
• Fertility and obstetrical complications in women with LMNA-related familial partial lipodystrophy. 23 Mar 2008

See a longer list of these articles.

Technical information about 'Lipodystrophy, Familial Partial'

Definition: Inherited conditions characterized by the partial loss of ADIPOSE TISSUE, either confined to the extremities with normal or increased fat deposits on the face, neck and trunk (type 1), or confined to the loss of SUBCUTANEOUS FAT from the limbs and trunk (type 2).

Descriptor UI: D052496

Alternative terms: Lipodystrophy, Familial Partial; Familial Partial Lipodystrophies; Lipodystrophies, Familial Partial; Partial Lipodystrophies, Familial; Partial Lipodystrophy, Familial; Koberling-Dunnigan Syndrome; Koberling Dunnigan Syndrome; Familial Partial Lipodystrophy; Familial Partial Lipodystrophy, Type 2; Lipodystrophy, Familial Partial, Dunnigan Type; Dunnigan Syndrome; Syndrome, Dunnigan; Lipodystrophy, Familial Partial, Type 2; Familial Partial Lipodystrophy, Type 3; Lipodystrophy, Familial Partial, Type 3; Familial Partial Lipodystrophy, Type 1; Familial Partial Lipodystrophy, Kobberling Type; Lipodystrophy, Familial Partial, Type 1;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C17.800.849.391.700; C18.452.584.625.700; C18.452.880.391.700;

History Note: 2007; use DIABETES MELLITUS, LIPOATROPHIC 2005-2006