Liver - Drug effects
Research News and Information

Sunday, November 22, 2009

The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity.

13 Nov 2009 Hepatocellular carcinoma (HCC) is the fifth most commonly occurring cancer worldwide. The expression of p27 has been related to reduced severity of tumor grade and recurrence of HCC. The study assessed the role of p27 on the cell proliferation and ... Read more...

High fat and highly thermolyzed fat diets promote insulin resistance and increase DNA damage in rats.

30 Oct 2009 Many studies have demonstrated that DNA damage may be associated with type 2 diabetes mellitus (T2DM) and its complications. The goal of this study was to evaluate the effects of the potential relationship between fat (thermolyzed) intake, glucose ... Read more...

Blood glutathione peroxidase-1 mRNA levels can be used as molecular biomarkers to determine dietary selenium requirements in rats.

30 Oct 2009 Transcript (mRNA) levels are increasingly being used in medicine as molecular biomarkers for disease and disease risk, including use of whole blood as a target tissue for analysis. Development of blood molecular biomarkers for nutritional status, ... Read more...

Latest indexed articles for 'Liver - Drug effects'

These are the very latest articles for this heading:

• The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity. 13 Nov 2009
• High fat and highly thermolyzed fat diets promote insulin resistance and increase DNA damage in rats. 30 Oct 2009
• Blood glutathione peroxidase-1 mRNA levels can be used as molecular biomarkers to determine dietary selenium requirements in rats. 30 Oct 2009
• Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes. 6 Oct 2009
• Nrf2 and antioxidant defense against CYP2E1 toxicity. 29 Sep 2009
• Liver tissue engineering in the evaluation of drug safety. 29 Sep 2009
• Effects of fenofibrate on plasma and hepatic transaminase activities and hepatic transaminase gene expression in rats. 29 Sep 2009
• Herbal toxicity. 29 Sep 2009
• Hepatic drug transporters, old and new: pharmacogenomics, drug response, and clinical relevance. 29 Sep 2009
• Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha. 29 Sep 2009
• Molecular mechanism of endotoxin tolerance. 29 Sep 2009
• Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. 23 Sep 2009
• Hyper- and hypo-induction of cytochrome P450 activities with Aroclor 1254 and 3-methylcholanthrene in Cyp1a2(-/-) mice. 18 Sep 2009
• Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects. 14 Sep 2009
• [Hepatotoxicity of statins] 11 Sep 2009
• [Elevation of liver enzymes in a patient with chronic hepatitis B during alpha-interferon treatment: what is it all about?] 8 Sep 2009
• Enhancement of ligand-dependent down-regulation of glucocorticoid receptor by lipopolysaccharide. 31 Aug 2009
• Ethyl-eicosapentaenoic acid reduces liver lipids and lowers plasma levels of lipids in mice fed a high-fat diet. 30 Aug 2009
• Absence of transaminase elevation during concomitant methotrexate and isoniazid therapy. 30 Aug 2009
• [Hepatic adverse effects of allopurinol] 30 Aug 2009

See a longer list of these articles.

Technical information about 'Liver'

Descriptor UI: D008099

Alternative terms: Liver; Livers;

Related Mesh Headings: Hepatectomy;

Allowable Qualifiers: abnormalities; anatomy & histology; blood supply; cytology; drug effects; embryology; enzymology; growth & development; immunology; injuries; innervation; metabolism; microbiology; parasitology; pathology; physiology; physiopathology; radiation effects; radiography; radionuclide imaging; secretion; surgery; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A03.620;

History Note: /cytology was LIVER CYTOLOGY 1964-65; /enzymology was LIVER ENZYMOLOGY 1964-65; /physiology was LIVER FUNCTION 1964-65

Technical Notes: /blood supply: consider also LIVER CIRCULATION; /cytol: consider also KUPFFER CELLS; /surg: consider also HEPATECTOMY & LIVER TRANSPLANTATION; inflammation = HEPATITIS & its specifics; specialty is HEPATOLOGY see GASTROENTEROLOGY; be careful: do not confuse "hepatic" with "intrahepatic": "intrahepatic" may refer to BILE DUCTS, INTRAHEPATIC & its dis, not LIVER