Long-Term Potentiation - Genetics
Research News and Information

Sunday, November 22, 2009

Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability.

2 Nov 2009 The effects of lifelong, moderate excess release of glutamate (Glu) in the CNS have not been previously characterized. We created a transgenic (Tg) mouse model of lifelong excess synaptic Glu release in the CNS by introducing the gene for glutamate ... Read more...

NMDA receptor phosphorylation at a site affected in schizophrenia controls synaptic and behavioral plasticity.

21 Sep 2009 Phosphorylation of the NR1 subunit of NMDA receptors (NMDARs) at serine (S) 897 is markedly reduced in schizophrenia patients. However, the role of NR1 S897 phosphorylation in normal synaptic function and adaptive behaviors are unknown. To address ... Read more...

The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice.

14 Sep 2009 Granulocyte-colony stimulating factor (G-CSF) is a hematopoietic growth factor that controls proliferation and differentiation of neural stem cells. Although recent studies have begun to explore G-CSF-related mechanisms of action in various disease ... Read more...

Latest indexed articles for 'Long-Term Potentiation - Genetics'

These are the very latest articles for this heading:

• Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability. 2 Nov 2009
• NMDA receptor phosphorylation at a site affected in schizophrenia controls synaptic and behavioral plasticity. 21 Sep 2009
• The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice. 14 Sep 2009
• Intact long-term potentiation but reduced connectivity between neocortical layer 5 pyramidal neurons in a mouse model of Rett syndrome. 7 Sep 2009
• Reelin and apoE actions on signal transduction, synaptic function and memory formation. 11 Aug 2009
• Age-dependent impairment of spine morphology and synaptic plasticity in hippocampal CA1 neurons of a presenilin 1 transgenic mouse model of Alzheimer's disease. 10 Aug 2009
• Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex. 8 Aug 2009
• Attenuated phrenic long-term facilitation in orexin neuron-ablated mice. 3 Aug 2009
• Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. 28 Jul 2009
• Impaired long-term stability of CA1 place cell representation in mice lacking the transcription factor zif268/egr1. 23 Jun 2009
• Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory. 23 Jun 2009
• Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release. 15 May 2009
• The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. 4 May 2009
• Activity pattern-dependent long-term potentiation in neocortex and hippocampus of GluA1 (GluR-A) subunit-deficient mice. 27 Apr 2009
• Sleep-dependent gene expression in the hippocampus and prefrontal cortex following long-term potentiation. 18 Apr 2009
• Genetic differences in hippocampal synaptic plasticity. 26 Mar 2009
• Environmental enrichment restores memory functioning in mice with impaired IL-1 signaling via reinstatement of long-term potentiation and spine size enlargement. 16 Mar 2009
• Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampus. 27 Feb 2009
• Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models. 23 Feb 2009
• Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. 22 Feb 2009

See a longer list of these articles.

Technical information about 'Long-Term Potentiation'

Definition: A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.

Descriptor UI: D017774

Alternative terms: Long-Term Potentiation; Long Term Potentiation; Long-Term Potentiations; Potentiation, Long-Term; Potentiations, Long-Term;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G11.561.600.635.350;

History Note: 94

Technical Notes: note category: "a persistent increase in synaptic efficacy"; DF: LTP