Long-Term Synaptic Depression
Research News and Information

Sunday, November 22, 2009

LTD induction suppresses LTP-induced hippocampal adult neurogenesis.

21 Sep 2009 Neurogenesis persists in certain adult brain regions including the dentate gyrus. Recent studies have shown that long-term potentiation (LTP) induction in the afferent pathway enhances adult neurogenesis in the dentate gyrus. Here, we investigated ... Read more...

Two forms of long-term depression in a polysynaptic pathway in the leech CNS: one NMDA receptor-dependent and the other cannabinoid-dependent.

4 Aug 2009 Although long-term depression (LTD) is a well-studied form of synaptic plasticity, it is clear that multiple cellular mechanisms are involved in its induction. In the leech, LTD is observed in a polysynaptic connection between touch mechanosensory ... Read more...

Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule.

2 Aug 2009 The detailed characterization of synaptic plasticity has led to the replacement of simple Hebbian rules by more complex rules depending on the order of presynaptic and postsynaptic action potentials. Here, we describe a mechanism endowing a ... Read more...

Latest indexed articles for 'Long-Term Synaptic Depression'

These are the very latest articles for this heading:

• LTD induction suppresses LTP-induced hippocampal adult neurogenesis. 21 Sep 2009
• Two forms of long-term depression in a polysynaptic pathway in the leech CNS: one NMDA receptor-dependent and the other cannabinoid-dependent. 4 Aug 2009
• Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule. 2 Aug 2009
• Toward a microscopic model of bidirectional synaptic plasticity. 28 Jul 2009
• L-type voltage-dependent calcium channel antagonists impair perirhinal long-term recognition memory and plasticity processes. 27 Jul 2009
• Diversity in long-term synaptic plasticity at inhibitory synapses of striatal spiny neurons. 22 Jul 2009
• Rescue of abnormal phenotypes in delta2 glutamate receptor-deficient mice by the extracellular N-terminal and intracellular C-terminal domains of the delta2 glutamate receptor. 13 Jul 2009
• Metaplastic regulation of long-term potentiation/long-term depression threshold by activity-dependent changes of NR2A/NR2B ratio. 6 Jul 2009
• Differential modulation of long-term depression by acute stress in the rat dorsal and ventral hippocampus. 6 Jul 2009
• An alternate cAMP pathway Epac promotes hippocampal long-term depression. 29 Jun 2009
• Modulation of LTP/LTD balance in STDP by an activity-dependent feedback mechanism. 28 Jun 2009
• Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. 23 Jun 2009
• Metaplasticity of hypothalamic synapses following in vivo challenge. 23 Jun 2009
• Role of presynaptic kainate receptors at parallel fiber-purkinje cell synapses in induction of cerebellar LTD: interplay with climbing fiber input. 15 Jun 2009
• Unconjugated bilirubin exposure impairs hippocampal long-term synaptic plasticity. 9 Jun 2009
• Inhibitory plasticity in a lateral band improves cortical detection of natural vocalizations. 9 Jun 2009
• Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics. 9 Jun 2009
• betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses. 5 Jun 2009
• Cannabinoid CB1 receptor-dependent long-term depression in autaptic excitatory neurons. Jun 2009
• Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability. 27 May 2009

See a longer list of these articles.

Technical information about 'Long-Term Synaptic Depression'

Definition: A persistent activity-dependent decrease in synaptic efficacy between NEURONS. It typically occurs following repeated low-frequency afferent stimulation, but it can be induced by other methods. Long-term depression appears to play a role in MEMORY.

Descriptor UI: D036881

Alternative terms: Long-Term Synaptic Depression; Long Term Synaptic Depression; Synaptic Depression, Long-Term; Long-Term Depression, Physiological; Depression, Physiological Long-Term; Depressions, Physiological Long-Term; Long Term Depression, Physiological; Long-Term Depressions, Physiological; Physiological Long-Term Depression; Physiological Long-Term Depressions; Long-Term Depression, Neurophysiological; Depression, Neurophysiological Long-Term; Depressions, Neurophysiological Long-Term; Long Term Depression, Neurophysiological; Long-Term Depressions, Neurophysiological; Neurophysiological Long-Term Depression; Neurophysiological Long-Term Depressions; Long-Term Depression, Physiologic; Long Term Depression, Physiologic; Physiologic Long-Term Depression; Long-Term Depression, Neurophysiologic; Long Term Depression, Neurophysiologic; Neurophysiologic Long-Term Depression; Depotentiation; Homosynaptic Depression; Depression, Homosynaptic;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G11.561.600.635.355;

History Note: 2008 (2003)

Technical Notes: note category: do not confuse with clinical DEPRESSION or DEPRESSIVE DISORDERS