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Lupus Erythematosus, Systemic - Pathology
Research News and Information
Definition of 'Lupus Erythematosus, Systemic'A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. |
Monday, November 23, 2009
13 Oct 2009 
OBJECTIVE: Systemic lupus erythematosus (SLE) has been associated with an increased risk of cardiovascular disease. However, prospective population-based data addressing this association have been lacking. METHODS: We conducted a prospective cohort ... Read more...
CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis.
2 Sep 2009 Infiltration of T cells into the kidney is a typical feature of human and experimental lupus nephritis that contributes to renal tissue injury. The chemokine receptor CXCR3 is highly expressed on Th1 cells and is supposed to be crucial for their ... Read more...
Predictors of damage progression in Portuguese patients with systemic lupus erythematosus.
30 Aug 2009 Patients with systemic lupus erythematosus (SLE) have a longer life expectancy. The occurrence of irreversible damage has become a major concern. The present study assessed damage progression in patients with SLE over a 2-year period and identified ... Read more...
Latest indexed articles for 'Lupus Erythematosus, Systemic - Pathology'
These are the very latest articles for this heading:
- Systemic lupus erythematosus and the risk of cardiovascular disease: results from the nurses' health study. 13 Oct 2009
- Blue (or purple) toes: chilblains or chilblain lupus-like lesions are a manifestation of Aicardi-Goutières syndrome and familial chilblain lupus.
29 Sep 2009 - Rituximab and lupus: good in real life, bad in controlled trials. Comment on the article by Lu et al. 13 Sep 2009
- CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. 2 Sep 2009
- Predictors of damage progression in Portuguese patients with systemic lupus erythematosus. 30 Aug 2009
- Rituximab use in pediatric autoimmune diseases: four case reports. 30 Aug 2009
- HLA in Portuguese systemic lupus erythematosus patients and their relation to clinical features. 30 Aug 2009
- Shared and unique gene expression in systemic lupus erythematosus depending on disease activity. 30 Aug 2009
- The role of iNKT cells in the immunopathology of systemic lupus erythematosus. 30 Aug 2009
- Autoimmune bullous dermatoses: a review. 30 Aug 2009
- Correlation between clinical activity and serological markers in a wide cohort of patients with systemic lupus erythematosus: an eight-year prospective study. 30 Aug 2009
- Devic's syndrome as initial presentation of systemic lupus erythematosus. 30 Aug 2009
- A new onset of systemic lupus erythematosus developed after bee venom therapy. 24 Aug 2009
- Detection of coronary artery lesions and myocardial necrosis by magnetic resonance in systemic necrotizing vasculitides. 13 Aug 2009
- Pseudoseptic arthritis due to acute lipoarthrosis in a systemic lupus erythematosus patient with osteonecrosis. 13 Aug 2009
- Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cells. 10 Aug 2009
- Long-term follow-up after non-myeloablative transplant of bone and marrow in BXSB mice. 30 Jul 2009
- Increased T-lymphocyte apoptosis in lupus correlates with disease activity and may be responsible for reduced T-cell frequency: a cross-sectional and longitudinal study. 30 Jul 2009
- The variable clinical picture of drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms in relation to the eliciting drug. 30 Jul 2009
- Subcutaneous panniculitis-like T-cell lymphoma with overlapping clinicopathologic features of lupus erythematosus: coexistence of 2 entities? 30 Jul 2009
See a longer list of these articles.
Technical information about 'Lupus Erythematosus, Systemic'
Definition: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Descriptor UI: D008180
Alternative terms: Lupus Erythematosus, Systemic; Systemic Lupus Erythematosus; Lupus Erythematosus Disseminatus; Libman-Sacks Disease; Disease, Libman-Sacks; Libman Sacks Disease;
Related Mesh Headings: Lupus Coagulation Inhibitor; Antiphospholipid Syndrome; Vasculitis, Central Nervous System;
Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C17.300.480; C20.111.590;
Technical Notes: if not specified as "systemic" it is still probably correct to index here, not also discoid; LUPUS NEPHRITIS is also available; LE CELLS see NEUTROPHILS is also available: use LUPUS ERYTHEMATOSUS, SYSTEMIC /blood or /pathol + NEUTROPHILS for discussion of the LE cells as cells; DF: SLE