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Lupus Erythematosus, Systemic
Research News and Information
Definition of 'Lupus Erythematosus, Systemic'A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. |
Sunday, March 21, 2010
13 Oct 2009 
OBJECTIVE: Systemic lupus erythematosus (SLE) has been associated with an increased risk of cardiovascular disease. However, prospective population-based data addressing this association have been lacking. METHODS: We conducted a prospective cohort ... Read more...
25-hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus.
13 Oct 2009 OBJECTIVE: Low serum levels of 25-hydroxyvitamin D (25[OH]D; vitamin D) are associated with a higher frequency of cardiovascular disease and risk factors in the general population. Vitamin D deficiency has also been noted in systemic lupus ... Read more...
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.
29 Sep 2009 Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of chronic immune responses and prevention of autoimmunity. Accordingly, mutations in their genes cause severe ... Read more...
Latest indexed articles for 'Lupus Erythematosus, Systemic'
These are the very latest articles for this heading:
- Antinuclear antibodies directed against proliferating cell nuclear antigen are not specifically associated with systemic lupus erythematosus.
30 Oct 2009 - Systemic lupus erythematosus and the risk of cardiovascular disease: results from the nurses' health study. 13 Oct 2009
- Population-based lupus registries: advancing our epidemiologic understanding. 13 Oct 2009
- 25-hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus. 13 Oct 2009
- Effects of a 3-month course of rosuvastatin in patients with systemic lupus erythematosus. 29 Sep 2009
- Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. 29 Sep 2009
- Blue (or purple) toes: chilblains or chilblain lupus-like lesions are a manifestation of Aicardi-Goutières syndrome and familial chilblain lupus. 29 Sep 2009
- Novel evidence-based systemic lupus erythematosus responder index. 13 Sep 2009
- Disease activity and damage are not associated with increased levels of fatigue in systemic lupus erythematosus patients from a multiethnic cohort: LXVII. 13 Sep 2009
- A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus. 13 Sep 2009
- Frequency and determinants of flare and persistently active disease in systemic lupus erythematosus. 13 Sep 2009
- Rituximab and lupus: good in real life, bad in controlled trials. Comment on the article by Lu et al. 13 Sep 2009
- The impact of flare on disease costs of patients with systemic lupus erythematosus. 13 Sep 2009
- A 65-year-old man with longstanding seropositive rheumatoid arthritis and lower extremity ulceration. 13 Sep 2009
- XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development. 12 Sep 2009
- CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. 2 Sep 2009
- Unraveling the etiology of systemic autoimmune diseases: peering into the preclinical phase of disease. 30 Aug 2009
- Drug-induced lupus associated with infliximab and adalimumab in an adolescent with Crohn disease. 30 Aug 2009
- Systemic lupus erythematosus and myasthenia gravis. 30 Aug 2009
- Current world literature. 30 Aug 2009
See a longer list of these articles.
Technical information about 'Lupus Erythematosus, Systemic'
Definition: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Descriptor UI: D008180
Alternative terms: Lupus Erythematosus, Systemic; Systemic Lupus Erythematosus; Lupus Erythematosus Disseminatus; Libman-Sacks Disease; Disease, Libman-Sacks; Libman Sacks Disease;
Related Mesh Headings: Lupus Coagulation Inhibitor; Antiphospholipid Syndrome; Vasculitis, Central Nervous System;
Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C17.300.480; C20.111.590;
Technical Notes: if not specified as "systemic" it is still probably correct to index here, not also discoid; LUPUS NEPHRITIS is also available; LE CELLS see NEUTROPHILS is also available: use LUPUS ERYTHEMATOSUS, SYSTEMIC /blood or /pathol + NEUTROPHILS for discussion of the LE cells as cells; DF: SLE