MAP Kinase Signaling System - Drug effects
Research News and Information

Sunday, November 22, 2009

Involvement of ATM-mediated Chk1/2 and JNK kinase signaling activation in HKH40A-induced cell growth inhibition.

29 Sep 2009 HKH40A (RTA 502), or 5-nitro-2-(3-{4-[3-(8-methoxy-6-oxo-6H-2,10b-diaza-aceanthrylen-5-ylamino)propyl]piperazin-1-yl}-propyl)-2-aza-phenalene-1,3-dione, has been shown to be a potent cell growth inhibitor. To investigate HKH40A actions, we focused ... Read more...

Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways.

29 Sep 2009 Osteosarcoma is characterized by a high malignant and metastatic potential. The chemokine stromal-derived factor-1alpha (SDF-1alpha) and its receptor, CXCR4, play a crucial role in adhesion and migration of human cancer cells. Integrins are the ... Read more...

Regulated expression of the alpha isoform of the human thromboxane A2 receptor during megakaryocyte differentiation: a coordinated role for WT1, Egr1, and Sp1.

6 Sep 2009 Thromboxane plays an essential role in hemostasis, regulating platelet aggregation and vessel tone. In humans, it signals through the TPalpha and TPbeta isoforms that are transcriptionally regulated by distinct promoters Prm1 and Prm3, respectively. ... Read more...

Latest indexed articles for 'MAP Kinase Signaling System - Drug effects'

These are the very latest articles for this heading:

• Involvement of ATM-mediated Chk1/2 and JNK kinase signaling activation in HKH40A-induced cell growth inhibition. 29 Sep 2009
• Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. 29 Sep 2009
• Regulated expression of the alpha isoform of the human thromboxane A2 receptor during megakaryocyte differentiation: a coordinated role for WT1, Egr1, and Sp1. 6 Sep 2009
• Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells. 3 Sep 2009
• VDR and MEK-ERK dependent induction of the antimicrobial peptide cathelicidin in keratinocytes by lithocholic acid. 3 Sep 2009
• Simultaneous detection of ERK-, p38-, and JNK-MAPK phosphorylation in human adipose-derived stem cells using the Cytometric Bead Array technology. Sep 2009
• Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus. Sep 2009
• Altered distribution and function of A2A adenosine receptors in the brain of WAG/Rij rats with genetic absence epilepsy, before and after appearance of the disease. 30 Aug 2009
• Inhibition of MEK signaling enhances the ability of cytarabine to induce growth arrest and apoptosis of acute myelogenous leukemia cells. 30 Aug 2009
• KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57(Kip2). 30 Aug 2009
• Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation. 29 Aug 2009
• Bacillus anthracis lethal toxin attenuates lipoteichoic acid-induced maturation and activation of dendritic cells through a unique mechanism. 29 Aug 2009
• GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib. 25 Aug 2009
• Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. 24 Aug 2009
• RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. 23 Aug 2009
• PMA induces expression from the herpes simplex virus thymidine kinase promoter via the activation of JNK and ERK in the presence of adenoviral E1A proteins. 21 Aug 2009
• Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling. 13 Aug 2009
• Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction. 12 Aug 2009
• Leishmania major parasites induced macrophage tolerance: implication of MAPK and NF-kappaB pathways. 11 Aug 2009
• Follistatin gene expression by gonadotropin-releasing hormone: a role for cyclic AMP and mitogen-activated protein kinase signaling pathways in clonal gonadotroph LbetaT2 cells. 11 Aug 2009

See a longer list of these articles.

Technical information about 'MAP Kinase Signaling System'

Definition: An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.

Descriptor UI: D020935

Alternative terms: MAP Kinase Signaling System; MAP Kinase Signaling Pathways; MAP Kinase Cascade; Cascade, MAP Kinase; Cascades, MAP Kinase; Kinase Cascade, MAP; Kinase Cascades, MAP; MAP Kinase Cascades; MAP Kinase Modules; Kinase Module, MAP; Kinase Modules, MAP; MAP Kinase Module; Module, MAP Kinase; Modules, MAP Kinase; MAP Kinase Signaling Cascades;

Related Mesh Headings: Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase Kinases; MAP Kinase Kinase Kinases;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G02.111.087.800.560; G02.149.115.800.560; G03.495.553.560; G04.299.880.560;

History Note: 2000