MAP Kinase Signaling System - Physiology
Research News and Information

Saturday, November 21, 2009

Nemo-like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells.

29 Sep 2009 BACKGROUND: The mitogen-activated protein kinases (MAPKs) regulate cell growth, differentiation, and stress responses, and many critical signaling pathways are subject to cross-regulation by MAPK signaling. Previous studies have yielded evidence of ... Read more...

Altered distribution and function of A2A adenosine receptors in the brain of WAG/Rij rats with genetic absence epilepsy, before and after appearance of the disease.

30 Aug 2009 The involvement of excitatory adenosine A(2A) receptors (A(2A)Rs), which probably contribute to the pathophysiology of convulsive seizures, has never been investigated in absence epilepsy. Here, we examined the distribution and function of A(2A)Rs ... Read more...

p75 neurotrophin receptor is implicated in the ability of neurotrophin-3 to negatively modulate activated ERK1/2 signaling in TrkA-expressing adult sensory neurons.

30 Aug 2009 Neurotrophin-3 (NT-3) can negatively modulate trkA and associated phenotype in intact sensory neurons, while positively regulating trkC and associated phenotype. How NT-3 effects this response is not clear. Whether NT-3 exerts a differential ... Read more...

Latest indexed articles for 'MAP Kinase Signaling System - Physiology'

These are the very latest articles for this heading:

• Nemo-like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells. 29 Sep 2009
• Altered distribution and function of A2A adenosine receptors in the brain of WAG/Rij rats with genetic absence epilepsy, before and after appearance of the disease. 30 Aug 2009
• p75 neurotrophin receptor is implicated in the ability of neurotrophin-3 to negatively modulate activated ERK1/2 signaling in TrkA-expressing adult sensory neurons. 30 Aug 2009
• Multivariate statistical analysis applied to an IL6 signal transduction model in hepatocytes. 28 Aug 2009
• Effects of osmolytes on the SLN1-YPD1-SSK1 phosphorelay system from Saccharomyces cerevisiae. 23 Aug 2009
• The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function. 16 Aug 2009
• 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. 16 Aug 2009
• Protein phosphatase 5 protects neurons against amyloid-beta toxicity. 15 Aug 2009
• Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors. 8 Aug 2009
• Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction. 4 Aug 2009
• Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts. 4 Aug 2009
• VEGF and RANKL regulation of NFATc1 in heart valve development. 4 Aug 2009
• Cytoprotective effect of polypeptide from Chlamys farreri on neuroblastoma (SH-SY5Y) cells following HO exposure involves scavenging ROS and inhibition JNK phosphorylation. Aug 2009
• Porcine pluripotency cell signaling develops from the inner cell mass to the epiblast during early development. 30 Jul 2009
• Activation of extracellular signal-regulated kinases during dehydration in the African clawed frog, Xenopus laevis. 30 Jul 2009
• B7-H1 expression is regulated by MEK/ERK signaling pathway in anaplastic large cell lymphoma and Hodgkin lymphoma. 30 Jul 2009
• TpMRK regulates cell division of Tetrahymena in response to oxidative stress. 30 Jul 2009
• The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line. 30 Jul 2009
• Quantitative cell signalling analysis reveals down-regulation of MAPK pathway activation in colorectal cancer. 30 Jul 2009
• Interactions between mitogen-activated protein kinase and protein kinase C signaling during oocyte maturation and fertilization in a marine worm. 30 Jul 2009

See a longer list of these articles.

Technical information about 'MAP Kinase Signaling System'

Definition: An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.

Descriptor UI: D020935

Alternative terms: MAP Kinase Signaling System; MAP Kinase Signaling Pathways; MAP Kinase Cascade; Cascade, MAP Kinase; Cascades, MAP Kinase; Kinase Cascade, MAP; Kinase Cascades, MAP; MAP Kinase Cascades; MAP Kinase Modules; Kinase Module, MAP; Kinase Modules, MAP; MAP Kinase Module; Module, MAP Kinase; Modules, MAP Kinase; MAP Kinase Signaling Cascades;

Related Mesh Headings: Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase Kinases; MAP Kinase Kinase Kinases;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G02.111.087.800.560; G02.149.115.800.560; G03.495.553.560; G04.299.880.560;

History Note: 2000