MAP Kinase Signaling System
Research News and Information

Saturday, November 21, 2009

Using cells devoid of RAS proteins as tools for drug discovery.

30 Oct 2009 Mutational activation of RAS proteins occurs in nearly 30% of all human tumors. To date direct pharmacological inhibition of RAS oncoproteins has not been possible. As a consequence, current strategies are focusing on the development of inhibitors ... Read more...

The effects of electroacupuncture on TH1/TH2 cytokine mRNA expression and mitogen-activated protein kinase signaling pathways in the splenic T cells of traumatized rats.

30 Oct 2009 BACKGROUND: Surgical trauma contributes to postoperative immune suppression, which is associated with an increased susceptibility to subsequent infections. Electroacupuncture (EA) can alleviate pain and exert immunoregulatory effects. However, the ... Read more...

EGFRvIII-induced estrogen-independence, tamoxifen-resistance phenotype correlates with PgR expression and modulation of apoptotic molecules in breast cancer.

30 Oct 2009 The tumor-specific, ligand-independent, constitutively active epidermal growth factor receptor (EGFR) variant, EGFRvIII, remains understudied in breast cancer. Here, we report that expression of EGFRvIII in the ErbB-2-overexpressing, ... Read more...

Latest indexed articles for 'MAP Kinase Signaling System'

These are the very latest articles for this heading:

• Using cells devoid of RAS proteins as tools for drug discovery. 30 Oct 2009
• The effects of electroacupuncture on TH1/TH2 cytokine mRNA expression and mitogen-activated protein kinase signaling pathways in the splenic T cells of traumatized rats. 30 Oct 2009
• EGFRvIII-induced estrogen-independence, tamoxifen-resistance phenotype correlates with PgR expression and modulation of apoptotic molecules in breast cancer. 30 Oct 2009
• The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells. 10 Oct 2009
• The phosphatase SHP2 regulates the spacing effect for long-term memory induction. 30 Sep 2009
• Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. 30 Sep 2009
• It's all about timing. 30 Sep 2009
• Prion protein and its ligand stress inducible protein 1 regulate astrocyte development. 29 Sep 2009
• Nemo-like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells. 29 Sep 2009
• Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis. 29 Sep 2009
• Involvement of ATM-mediated Chk1/2 and JNK kinase signaling activation in HKH40A-induced cell growth inhibition. 29 Sep 2009
• Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. 29 Sep 2009
• Osteopontin increases migration and MMP-9 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells. 29 Sep 2009
• Regulated expression of the alpha isoform of the human thromboxane A2 receptor during megakaryocyte differentiation: a coordinated role for WT1, Egr1, and Sp1. 6 Sep 2009
• Glomus tumors in neurofibromatosis type 1: genetic, functional, and clinical evidence of a novel association. 6 Sep 2009
• Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells. 3 Sep 2009
• VDR and MEK-ERK dependent induction of the antimicrobial peptide cathelicidin in keratinocytes by lithocholic acid. 3 Sep 2009
• The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. 2 Sep 2009
• Simultaneous detection of ERK-, p38-, and JNK-MAPK phosphorylation in human adipose-derived stem cells using the Cytometric Bead Array technology. Sep 2009
• Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus. Sep 2009

See a longer list of these articles.

Technical information about 'MAP Kinase Signaling System'

Definition: An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.

Descriptor UI: D020935

Alternative terms: MAP Kinase Signaling System; MAP Kinase Signaling Pathways; MAP Kinase Cascade; Cascade, MAP Kinase; Cascades, MAP Kinase; Kinase Cascade, MAP; Kinase Cascades, MAP; MAP Kinase Cascades; MAP Kinase Modules; Kinase Module, MAP; Kinase Modules, MAP; MAP Kinase Module; Module, MAP Kinase; Modules, MAP Kinase; MAP Kinase Signaling Cascades;

Related Mesh Headings: Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase Kinases; MAP Kinase Kinase Kinases;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G02.111.087.800.560; G02.149.115.800.560; G03.495.553.560; G04.299.880.560;

History Note: 2000