Matrix Metalloproteinase 3 - Biosynthesis
Research News and Information

Thursday, March 11, 2010

Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression.

30 Jul 2009 Platelet-rich plasma (PRP) has generated substantial interest for tendon and ligament regeneration because of the high concentrations of growth factors in platelet alpha-granules. This study compared the temporal release of growth factors from bone ... Read more...

Tendon degeneration is not mediated by regulation of Toll-like receptors 2 and 4 in human tenocytes.

30 Jul 2009 We hypothesized that expression of Toll-like receptors (TLRs) 2 and 4 by tenocytes is involved in the catabolic processes of tendon degeneration. We investigated TLR2 and TLR4 expression by tenocytes in healthy and tendinotic Achilles tendons. We ... Read more...

Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein.

14 Jul 2009 Tissue-type plasminogen activator (t-PA) is approved for treatment of ischemic stroke patients, but it increases the risk of intracranial bleeding (ICB). Previously, we have shown in a mouse stroke model that stromelysin-1 (matrix ... Read more...

Latest indexed articles for 'Matrix Metalloproteinase 3 - Biosynthesis'

These are the very latest articles for this heading:

• Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. 30 Jul 2009
• Tendon degeneration is not mediated by regulation of Toll-like receptors 2 and 4 in human tenocytes. 30 Jul 2009
• Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein. 14 Jul 2009
• Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. 8 Jun 2009
• Identification of an active site of EMMPRIN for the augmentation of matrix metalloproteinase-1 and -3 expression in a co-culture of human uterine cervical carcinoma cells and fibroblasts. 6 May 2009
• Cholinoceptor modulation on nitric oxide regulates prostaglandin E(2) and metalloproteinase-3 production in experimentally induced inflammation of rat dental pulp. 30 Mar 2009
• Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. 9 Mar 2009
• [Clinical significance of functional variants of matrix metalloproteinase genes in thyroid cancer] 30 Dec 2008
• Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. 30 Dec 2008
• Immunological investigation of the hepatic tissue from infants with biliary atresia. 15 Dec 2008
• Inhibition of IL-1beta-mediated inflammatory responses by the IkappaB alpha super-repressor in human fibroblast-like synoviocytes. 9 Nov 2008
• Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy. 30 Jul 2008
• Inhibition by a selective IkappaB kinase-2 inhibitor of interleukin-1-induced collagen degradation by corneal fibroblasts in three-dimensional culture. 30 Jul 2008
• Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation. 28 Jul 2008
• Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins. 28 Jun 2008
• Keratinocytes modify fibroblast metabolism in hereditary gingival fibromatosis. 25 Jun 2008
• Comparative analysis of immunohistochemical markers with invasiveness and histologic differentiation in squamous cell carcinoma and basal cell carcinoma of the skin. 30 May 2008
• Endothelins stimulate the production of stromelysin-1 in cultured rat astrocytes. 21 Apr 2008
• Role of hypoxia-inducible factor-1alpha in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes. 7 Apr 2008
• Matrix metalloproteinase-3 induction in rat brain astrocytes: focus on the role of two AP-1 elements. 13 Mar 2008

See a longer list of these articles.

Technical information about 'Matrix Metalloproteinase 3'

Definition: An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)

Registry Number: EC 3.4.24.17

Descriptor UI: D019278

Alternative terms: Matrix Metalloproteinase 3; Metalloproteinase 3, Matrix; Transin; Stromelysin; Stromelysin 1; MMP-3 Metalloproteinase; MMP 3 Metalloproteinase; Metalloproteinase, MMP-3; MMP3 Metalloproteinase; Metalloproteinase, MMP3;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.656.300.480.525.700.200; D08.811.277.656.675.374.525.700.200;

History Note: 2007(1997)

Technical Notes: /antag is permitted but TISSUE INHIBITOR OF METALLOPROTEINASE-3 is available