Mecamylamine - Pharmacology
Research News and Information

Sunday, November 22, 2009

Nicotine activates the chemosensory cation channel TRPA1.

11 Sep 2009 Topical application of nicotine, as used in nicotine replacement therapies, causes irritation of the mucosa and skin. This reaction has been attributed to activation of nicotinic acetylcholine receptors (nAChRs) in chemosensory neurons. In contrast ... Read more...

Rostral ventral medulla cholinergic mechanism in pain-induced analgesia.

18 Aug 2009 The ascending nociceptive control (ANC), a novel spinostriatal pain modulation pathway, mediates a form of pain-induced analgesia referred to as noxious stimulus-induced antinociception (NSIA). ANC includes specific spinal cord mechanisms as well as ... Read more...

Selective potentiation of crossed vs. uncrossed inputs from lateral geniculate nucleus to visual cortex by the basal forebrain: potential facilitation of rodent binocularity.

21 Jul 2009 Cholinergic projections originating in the basal forebrain (BF) play important roles in the heterosynaptic facilitation of synaptic strength in various sensory cortices, including the primary visual cortex (V1). Here, using urethane-anesthetized ... Read more...

Latest indexed articles for 'Mecamylamine - Pharmacology'

These are the very latest articles for this heading:

• Nicotine activates the chemosensory cation channel TRPA1. 11 Sep 2009
• Rostral ventral medulla cholinergic mechanism in pain-induced analgesia. 18 Aug 2009
• Selective potentiation of crossed vs. uncrossed inputs from lateral geniculate nucleus to visual cortex by the basal forebrain: potential facilitation of rodent binocularity. 21 Jul 2009
• The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices. 21 Jul 2009
• Effects of galantamine on L-NAME-induced behavioral impairment in Y-maze task in mice. 13 Jul 2009
• Cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials. 20 Jun 2009
• Behavioral and neurotoxic effects of arsenic exposure in zebrafish (Danio rerio, Teleostei: Cyprinidae). 4 Jun 2009
• Involvement of the cholinergic system in the central histamine-induced reversal of critical haemorrhagic hypotension in rats. 30 May 2009
• Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis. 30 May 2009
• Effects of mecamylamine on alcohol consumption and preference in male C57BL/6J mice. 18 May 2009
• Sympathetic-correlated c-Fos expression in the neonatal rat spinal cord in vitro. 29 Apr 2009
• Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex. 29 Apr 2009
• Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats. 21 Apr 2009
• Effects of mecamylamine on nicotine-induced conditioned hyperactivity and sensitization in differentially reared rats. 16 Apr 2009
• A novel touchscreen-automated paired-associate learning (PAL) task sensitive to pharmacological manipulation of the hippocampus: a translational rodent model of cognitive impairments in neurodegenerative disease. 7 Apr 2009
• Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice. 5 Apr 2009
• The role of the AT4 and cholinergic systems in the Nucleus Basalis Magnocellularis (NBM): effects on spatial memory. 23 Mar 2009
• Chronic nicotine exposure switches the functional role of mesolimbic dopamine transmission in the processing of nicotine's rewarding and aversive effects. 27 Feb 2009
• Alternating low frequency stimulation of medial septal and commissural fibers induces NMDA-dependent, long-lasting potentiation of hippocampal synapses in urethane-anesthetized rats. 27 Feb 2009
• Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice. 25 Feb 2009

See a longer list of these articles.

Technical information about 'Mecamylamine'

Definition: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Chemical name: Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl-

Registry Number: 60-40-2

Descriptor UI: D008464

Alternative terms: Mecamylamine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Antihypertensive Agents; Ganglionic Blockers; Nicotinic Antagonists;

Tree Number: D02.455.849.575.781.500;