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Melanoma - Genetics
Research News and Information
Definition of 'Melanoma'A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) |
Sunday, November 22, 2009
30 Oct 2009 
Regulations of intracellular protein kinase C (PKC) on carbachol (CCh)-induced intracellular calcium ([Ca(2+)]i) responses were investigated in different stages of melanoma cells. We found that CCh (1 mM) significantly increased [Ca(2+)]i with 6-, ... Read more...
Family history of melanoma and Parkinson disease risk.
18 Oct 2009 BACKGROUND: Co-occurrence of Parkinson disease (PD) and melanoma has been reported in numerous studies. If this was due to common genetic mechanisms, a positive family history of melanoma would be associated with an excessive PD risk, independent of ... Read more...
Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populations.
13 Oct 2009 Variation within the melanocortin receptor 1 (MC1R) gene, that influences phenotypic traits and susceptibility to melanoma, is abundant across the populations. We assessed and compared the risk of melanoma in 2 European populations, German and ... Read more...
Latest indexed articles for 'Melanoma - Genetics'
These are the very latest articles for this heading:
- Negative regulation of endogenous protein kinase Calpha on the dynamic change of carbachol-induced intracellular calcium response in different melanoma cells. 30 Oct 2009
- Family history of melanoma and Parkinson disease risk. 18 Oct 2009
- Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populations. 13 Oct 2009
- A therapeutic opportunity in melanoma: ErbB4 makes a mark on skin. 4 Oct 2009
- Selection criteria for genetic assessment of patients with familial melanoma. 29 Sep 2009
- Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways. 11 Sep 2009
- Profiling and discovery of novel miRNAs from formalin-fixed, paraffin-embedded melanoma and nodal specimens. 30 Aug 2009
- Targets of protective tumor immunity. 30 Aug 2009
- Cancer risk assessment for the primary care physician. 30 Aug 2009
- Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression. 30 Aug 2009
- Distinguishing epithelioid blue nevus from blue nevus-like cutaneous melanoma metastasis using fluorescence in situ hybridization. 30 Aug 2009
- Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells. 30 Aug 2009
- Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. 28 Aug 2009
- DNA repair gene polymorphisms and risk of cutaneous melanoma: a systematic review and meta-analysis. 23 Aug 2009
- Genome-wide associations studies for melanoma and nevi.
15 Aug 2009 - Overexpression of protease-activated receptor-1 contributes to melanoma metastasis via regulation of connexin 43. 13 Aug 2009
- Melanoma proliferation and chemoresistance controlled by the DEK oncogene. 13 Aug 2009
- Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians. 13 Aug 2009
- Melanoma-initiating cells: a compass needed. 12 Aug 2009
- Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma. 2 Aug 2009
See a longer list of these articles.
Technical information about 'Melanoma'
Definition: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Descriptor UI: D008545
Alternative terms: Melanoma; Melanomas; Malignant Melanoma; Malignant Melanomas; Melanoma, Malignant; Melanomas, Malignant;
Allowable Qualifiers: blood; blood supply; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; secondary; secretion; surgery; therapy; ultrastructure; urine; veterinary; ultrasonography; chemistry; virology;
Tree Number: C04.557.465.625.650.510; C04.557.580.625.650.510; C04.557.665.510;
Technical Notes: /blood supply /chem /second /secret /ultrastruct permitted; coord IM with precoord organ/neopl term (IM); MELANOMA, EXPERIMENTAL is also available