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Melanoma
Research News and Information
Definition of 'Melanoma'A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) |
Saturday, November 21, 2009
Administration of high-dose interleukin-2 in a 2-year-old with metastatic melanoma.
13 Dec 2009 
Malignant melanoma is rare in pediatrics, and therapies for patients with disseminated disease have not been well studied. This report describes our experience with the use of high-dose interleukin 2 (aldesleukin, IL-2) in a 2-year-old child with ... Read more...
Diagnostic value of CD163 in cutaneous spindle cell lesions.
22 Nov 2009 BACKGROUND: The histologic diagnosis of atypical fibroxanthoma (AFX) can sometimes be challenging. No specific marker exists to confirm the diagnosis other than excluding other entities. CD163 has been shown to have great specificity for tumors of ... Read more...
13 Nov 2009 Delimotecan (MEN 4901/T-0128) is a new cytotoxic prodrug constituted by a camptothecin analog (T-2513) bound to carboxymethyl dextran through a triglycine linker. A significant antitumor activity of delimotecan against human metastatic melanoma ... Read more...
Latest indexed articles for 'Melanoma'
These are the very latest articles for this heading:
- Administration of high-dose interleukin-2 in a 2-year-old with metastatic melanoma. 13 Dec 2009
- Diagnostic value of CD163 in cutaneous spindle cell lesions. 22 Nov 2009
- Antitumor activity of delimotecan against human metastatic melanoma: pharmacokinetics and molecular determinants. 13 Nov 2009
- In vivo major histocompatibility complex class I (MHCI) expression on MHCIlow tumor cells is regulated by gammadelta T and NK cells during the early steps of tumor growth. 31 Oct 2009
- Short length of stay and rapid recovery to normal function after surgery for metastatic melanoma to abdominal and retroperitoneal viscera. 30 Oct 2009
- Lymphatic invasion detected by D2-40/S-100 dual immunohistochemistry does not predict sentinel lymph node status in melanoma. 30 Oct 2009
- Stromal collagenase in melanoma: a vascular connection. 30 Oct 2009
- Modified heparins inhibit integrin alpha(IIb)beta(3) mediated adhesion of melanoma cells to platelets in vitro and in vivo. 30 Oct 2009
- Negative regulation of endogenous protein kinase Calpha on the dynamic change of carbachol-induced intracellular calcium response in different melanoma cells. 30 Oct 2009
- Images in clinical medicine. A swinging heart.
27 Oct 2009 - Family history of melanoma and Parkinson disease risk. 18 Oct 2009
- Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populations. 13 Oct 2009
- The invasive potential of human melanoma cell lines correlates with their ability to alter fibroblast gene expression in vitro and the stromal microenvironment in vivo. 13 Oct 2009
- A therapeutic opportunity in melanoma: ErbB4 makes a mark on skin. 4 Oct 2009
- Multiple blue macules and papules on the scalp. 29 Sep 2009
- A glimpse of future management of melanoma. 29 Sep 2009
- Reflectance confocal microscopy and features of melanocytic lesions: an internet-based study of the reproducibility of terminology. 29 Sep 2009
- Highly sensitive multivariable assay detection of melanocytic differentiation antigens and angiogenesis biomarkers in sentinel lymph nodes with melanoma micrometastases. 29 Sep 2009
- Topical mitomycin following cryotherapy for treatment of recurrent ocular surface melanoma. 29 Sep 2009
- Uveal effusion simulating uveal ring melanoma. 29 Sep 2009
See a longer list of these articles.
Technical information about 'Melanoma'
Definition: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Descriptor UI: D008545
Alternative terms: Melanoma; Melanomas; Malignant Melanoma; Malignant Melanomas; Melanoma, Malignant; Melanomas, Malignant;
Allowable Qualifiers: blood; blood supply; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; secondary; secretion; surgery; therapy; ultrastructure; urine; veterinary; ultrasonography; chemistry; virology;
Tree Number: C04.557.465.625.650.510; C04.557.580.625.650.510; C04.557.665.510;
Technical Notes: /blood supply /chem /second /secret /ultrastruct permitted; coord IM with precoord organ/neopl term (IM); MELANOMA, EXPERIMENTAL is also available