Mesangial Cells - Metabolism
Research News and Information

Monday, November 23, 2009

High ambient glucose induces angiotensin-independent AT-1 receptor activation, leading to increases in proliferation and extracellular matrix accumulation in MES-13 mesangial cells.

12 Sep 2009 Diabetic nephropathy is associated with mesangial ECM (extracellular matrix) accumulation. We have shown that AT-1R [Ang II (angiotensin II) type I receptor] signalling induces ECM proteins via transactivation of PI3K (phosphoinositide 3-kinase) in ... Read more...

Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanism.

31 Aug 2009 Transforming growth factor (TGF)-beta is a central mediator in the progression of glomerulosclerosis, leading to accumulation of aberrant extracellular matrix proteins and inappropriate expression of smooth muscle alpha-actin in the kidney. ... Read more...

Subcellular localization of Nox4 and regulation in diabetes.

15 Aug 2009 Oxidative stress is implicated in human diseases. Some of the oxidative pathways are harbored in the mitochondria. NAD(P)H oxidases have been identified not only in phagocytic but also in somatic cells. Nox4 is the most ubiquitous of these oxidases ... Read more...

Latest indexed articles for 'Mesangial Cells - Metabolism'

These are the very latest articles for this heading:

• High ambient glucose induces angiotensin-independent AT-1 receptor activation, leading to increases in proliferation and extracellular matrix accumulation in MES-13 mesangial cells. 12 Sep 2009
• Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanism. 31 Aug 2009
• Subcellular localization of Nox4 and regulation in diabetes. 15 Aug 2009
• Mechanisms underlying the antifibrotic properties of noninhibitory PAI-1 (PAI-1R) in experimental nephritis. 20 Jul 2009
• Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells. 11 Jul 2009
• Y-box protein 1 stimulates mesangial cell proliferation via activation of ERK1/2. 7 Jul 2009
• Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells. 5 Jul 2009
• Nitric oxide inhibits glomerular TGF-beta signaling via SMOC-1. 30 Jun 2009
• Pirfenidone is renoprotective in diabetic kidney disease. 30 Jun 2009
• Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid. 29 Jun 2009
• Comparison of antioxidant activity of cilnidipine and amlodipine. 29 Jun 2009
• Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells. 23 Jun 2009
• Human immunodeficiency virus downregulates podocyte apoE expression. 22 Jun 2009
• Regulation of glucose uptake in mesangial cells stimulated by high glucose: role of angiotensin II and insulin. 20 Jun 2009
• TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. 19 Jun 2009
• Cooperative activation of Npr1 gene transcription and expression by interaction of Ets-1 and p300. 30 May 2009
• Nifedipine, a calcium channel blocker, inhibits advanced glycation end product (AGE)-elicited mesangial cell damage by suppressing AGE receptor (RAGE) expression via peroxisome proliferator-activated receptor-gamma activation. 17 May 2009
• Crosstalk between peroxisome proliferator-activated receptor-gamma and angiotensin II in renal tubular epithelial cells in IgA nephropathy. 12 May 2009
• Cellular origins of type IV collagen networks in developing glomeruli. 5 May 2009
• Effects of advanced glycosylation end products and rosiglitazone on the expression and secretion of galectin-3 in human renal mesangial cells. 3 May 2009

See a longer list of these articles.

Technical information about 'Mesangial Cells'

Definition: Smooth muscle-like cells adhering to the wall of the small blood vessels of the KIDNEY at the glomerulus and along the vascular pole of the glomerulus in the JUXTAGLOMERULAR APPARATUS. They are myofibroblasts with contractile and phagocytic properties. These cells and their MESANGIAL EXTRACELLULAR MATRIX constitute the GLOMERULAR MESANGIUM.

Descriptor UI: D050527

Alternative terms: Mesangial Cells; Cell, Mesangial; Cells, Mesangial; Mesangial Cell; Renal Mesangial Cells; Cell, Renal Mesangial; Cells, Renal Mesangial; Mesangial Cell, Renal; Mesangial Cells, Renal; Renal Mesangial Cell; Mesangial Cells, Kidney; Cell, Kidney Mesangial; Cells, Kidney Mesangial; Kidney Mesangial Cell; Kidney Mesangial Cells; Mesangial Cell, Kidney; Extraglomerular Mesangial Cells; Cell, Extraglomerular Mesangial; Cells, Extraglomerular Mesangial; Extraglomerular Mesangial Cell; Mesangial Cell, Extraglomerular; Mesangial Cells, Extraglomerular; Lacis Cells; Cell, Lacis; Cells, Lacis; Lacis Cell; Glomerular Mesangial Cells; Cell, Glomerular Mesangial; Cells, Glomerular Mesangial; Glomerular Mesangial Cell; Mesangial Cell, Glomerular; Mesangial Cells, Glomerular; Renal Glomerulus Mesangial Cells;

Allowable Qualifiers: classification; cytology; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A05.810.453.324.359.620; A05.810.453.736.520.620; A11.329.228.950;

History Note: 2006