Mesangial Cells
Research News and Information

Sunday, November 22, 2009

High ambient glucose induces angiotensin-independent AT-1 receptor activation, leading to increases in proliferation and extracellular matrix accumulation in MES-13 mesangial cells.

12 Sep 2009 Diabetic nephropathy is associated with mesangial ECM (extracellular matrix) accumulation. We have shown that AT-1R [Ang II (angiotensin II) type I receptor] signalling induces ECM proteins via transactivation of PI3K (phosphoinositide 3-kinase) in ... Read more...

Mesangial cell-derived factors alter monocyte activation and function through inflammatory pathways: possible pathogenic role in diabetic nephropathy.

7 Sep 2009 Infiltration of macrophages to the kidney is a feature of early diabetic nephropathy. For this to happen monocytes must become activated, migrate from the circulation, and infiltrate the mesangium. This process involves degradation of extracellular ... Read more...

Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanism.

31 Aug 2009 Transforming growth factor (TGF)-beta is a central mediator in the progression of glomerulosclerosis, leading to accumulation of aberrant extracellular matrix proteins and inappropriate expression of smooth muscle alpha-actin in the kidney. ... Read more...

Latest indexed articles for 'Mesangial Cells'

These are the very latest articles for this heading:

• High ambient glucose induces angiotensin-independent AT-1 receptor activation, leading to increases in proliferation and extracellular matrix accumulation in MES-13 mesangial cells. 12 Sep 2009
• Mesangial cell-derived factors alter monocyte activation and function through inflammatory pathways: possible pathogenic role in diabetic nephropathy. 7 Sep 2009
• Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanism. 31 Aug 2009
• Viral RNA and DNA trigger common antiviral responses in mesangial cells. 25 Aug 2009
• Subcellular localization of Nox4 and regulation in diabetes. 15 Aug 2009
• Cytoprotection against hydrogen peroxide-induced cell death in cultured mouse mesangial cells by erigeroflavanone, a novel compound from the flowers of Erigeron annuus. 12 Aug 2009
• Mechanisms underlying the antifibrotic properties of noninhibitory PAI-1 (PAI-1R) in experimental nephritis. 20 Jul 2009
• Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions. 14 Jul 2009
• EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells. 13 Jul 2009
• Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells. 11 Jul 2009
• Y-box protein 1 stimulates mesangial cell proliferation via activation of ERK1/2. 7 Jul 2009
• Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells. 5 Jul 2009
• Nitric oxide inhibits glomerular TGF-beta signaling via SMOC-1. 30 Jun 2009
• Pirfenidone is renoprotective in diabetic kidney disease. 30 Jun 2009
• Renal and retinal effects of enalapril and losartan in type 1 diabetes. 30 Jun 2009
• The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility. 29 Jun 2009
• Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid. 29 Jun 2009
• Comparison of antioxidant activity of cilnidipine and amlodipine. 29 Jun 2009
• Effect of interleukin-6 receptor blockage on renal injury in apolipoprotein E-deficient mice. 29 Jun 2009
• Isolation and characterization of resident mesenchymal stem cells in human glomeruli. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Mesangial Cells'

Definition: Smooth muscle-like cells adhering to the wall of the small blood vessels of the KIDNEY at the glomerulus and along the vascular pole of the glomerulus in the JUXTAGLOMERULAR APPARATUS. They are myofibroblasts with contractile and phagocytic properties. These cells and their MESANGIAL EXTRACELLULAR MATRIX constitute the GLOMERULAR MESANGIUM.

Descriptor UI: D050527

Alternative terms: Mesangial Cells; Cell, Mesangial; Cells, Mesangial; Mesangial Cell; Renal Mesangial Cells; Cell, Renal Mesangial; Cells, Renal Mesangial; Mesangial Cell, Renal; Mesangial Cells, Renal; Renal Mesangial Cell; Mesangial Cells, Kidney; Cell, Kidney Mesangial; Cells, Kidney Mesangial; Kidney Mesangial Cell; Kidney Mesangial Cells; Mesangial Cell, Kidney; Extraglomerular Mesangial Cells; Cell, Extraglomerular Mesangial; Cells, Extraglomerular Mesangial; Extraglomerular Mesangial Cell; Mesangial Cell, Extraglomerular; Mesangial Cells, Extraglomerular; Lacis Cells; Cell, Lacis; Cells, Lacis; Lacis Cell; Glomerular Mesangial Cells; Cell, Glomerular Mesangial; Cells, Glomerular Mesangial; Glomerular Mesangial Cell; Mesangial Cell, Glomerular; Mesangial Cells, Glomerular; Renal Glomerulus Mesangial Cells;

Allowable Qualifiers: classification; cytology; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A05.810.453.324.359.620; A05.810.453.736.520.620; A11.329.228.950;

History Note: 2006