Methadone - Therapeutic use
Research News and Information

Sunday, November 22, 2009

Effectiveness of community treatments for heroin and crack cocaine addiction in England: a prospective, in-treatment cohort study.

29 Sep 2009 BACKGROUND: Addiction to heroin and crack cocaine is debilitating and persistent, but such disorders are treatable. We present the first effectiveness study of the main community interventions for addiction to heroin and crack cocaine in England, ... Read more...

Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial.

29 Sep 2009 CONTEXT: Cocaine dependence, which affects 2.5 million Americans annually, has no US Food and Drug Administration-approved pharmacotherapy. OBJECTIVES: To evaluate the immunogenicity, safety, and efficacy of a novel cocaine vaccine to treat cocaine ... Read more...

A selection model for longitudinal binary responses subject to non-ignorable attrition.

28 Aug 2009 Longitudinal studies collect information on a sample of individuals which is followed over time to analyze the effects of individual and time-dependent characteristics on the observed response. These studies often suffer from attrition: individuals ... Read more...

Latest indexed articles for 'Methadone - Therapeutic use'

These are the very latest articles for this heading:

• Effectiveness of community treatments for heroin and crack cocaine addiction in England: a prospective, in-treatment cohort study. 29 Sep 2009
• Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial. 29 Sep 2009
• A selection model for longitudinal binary responses subject to non-ignorable attrition. 28 Aug 2009
• Heroin prescription and history. 18 Aug 2009
• Diacetylmorphine versus methadone for the treatment of opioid addiction. 18 Aug 2009
• Proportional hazards frailty models for recurrent methadone maintenance treatment. 9 Aug 2009
• Opioid dependence treatment: options in pharmacotherapy. 30 Jul 2009
• [Opiate replacement therapy in France: assessment of the public policies] 28 Jul 2009
• Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program. 22 Jul 2009
• Sustained attention in patients receiving and abstinent following methadone maintenance treatment for opiate dependence: performance and neuroimaging results. 13 Jul 2009
• Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients. 12 Jul 2009
• The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) Prisons Project Study: protocol for a randomised controlled trial comparing methadone and buprenorphine for opiate detoxification. 12 Jul 2009
• Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence. 6 Jul 2009
• [Efficacy of intraoperative methadone and clonidine in pain control in the immediate postoperative period after the use of remifentanil] 29 Jun 2009
• 2009 Clinical Guidelines from the American Pain Society and the American Academy of Pain Medicine on the use of chronic opioid therapy in chronic noncancer pain: what are the key messages for clinical practice? 29 Jun 2009
• Overcoming obstacles to implementing methadone maintenance therapy for prisoners: implications for policy and practice. 29 Jun 2009
• Methadone for pain: limited evidence, tenuous guidelines. 29 Jun 2009
• Rhabdomyolysis and brain ischemic stroke in a heroin-dependent male. Invited comment. 29 Jun 2009
• Estimating incidence trends in regular heroin use in 26 regions of Switzerland using methadone treatment data. 10 Jun 2009
• Prevalence of problem alcohol use among patients attending primary care for methadone treatment. 9 Jun 2009

See a longer list of these articles.

Technical information about 'Methadone'

Definition: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

Chemical name: 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-

Registry Number: 76-99-3

Descriptor UI: D008691

Alternative terms: Methadone; Dolophine; Roxane Brand of Methadone Hydrochloride; Methadone Hydrochloride; Hydrochloride, Methadone; Phenadone; Physeptone; GlaxoSmithKline Brand of Methadone Hydrochloride; Martindale Brand of Methadone Hydrochloride; Phymet; Symoron; Yamanouchi Brand of Methadone Hydrochloride; Metadol; Pharmascience Brand of Methadone Hydrochloride; Metasedin; Esteve Brand of Methadone Hydrochloride; Methaddict; addiCare Brand of Methadone Hydrochloride; Methadose; Rosemont Brand of Methadone Hydrochloride; Mallinckrodt Brand of Methadone Hydrochloride; Methex; Generics Brand of Methadone Hydrochloride; Pinadone; Pinewood Brand of Methadone Hydrochloride; Amidone; Biodone; Biomet Brand of Methadone Hydrochloride;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Antitussive Agents; Narcotics; Analgesics, Opioid;

Tree Number: D02.522.675;

Technical Notes: with disease term, use /rehabil rather than /drug ther