Methadone
Research News and Information

Sunday, November 22, 2009

Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion.

30 Oct 2009 BACKGROUND: Methadone is an opioid agonist often given to manage acute and chronic pain. We sought to determine whether methadone compared with morphine dose dependently reduces myocardial infarct size (IS) and whether the mechanism is delta-opioid ... Read more...

Effectiveness of community treatments for heroin and crack cocaine addiction in England: a prospective, in-treatment cohort study.

29 Sep 2009 BACKGROUND: Addiction to heroin and crack cocaine is debilitating and persistent, but such disorders are treatable. We present the first effectiveness study of the main community interventions for addiction to heroin and crack cocaine in England, ... Read more...

Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial.

29 Sep 2009 CONTEXT: Cocaine dependence, which affects 2.5 million Americans annually, has no US Food and Drug Administration-approved pharmacotherapy. OBJECTIVES: To evaluate the immunogenicity, safety, and efficacy of a novel cocaine vaccine to treat cocaine ... Read more...

Latest indexed articles for 'Methadone'

These are the very latest articles for this heading:

• Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion. 30 Oct 2009
• Effectiveness of community treatments for heroin and crack cocaine addiction in England: a prospective, in-treatment cohort study. 29 Sep 2009
• Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial. 29 Sep 2009
• Struck from behind: maintaining quality of life with chronic low back pain. 30 Aug 2009
• Buprenorphine withdrawal in a toddler. 30 Aug 2009
• A selection model for longitudinal binary responses subject to non-ignorable attrition. 28 Aug 2009
• Heroin prescription and history. 18 Aug 2009
• Diacetylmorphine versus methadone for the treatment of opioid addiction. 18 Aug 2009
• Efficacy of prescribed injectable diacetylmorphine in the Andalusian trial: Bayesian analysis of responders and non-responders according to a multi domain outcome index. 12 Aug 2009
• Proportional hazards frailty models for recurrent methadone maintenance treatment. 9 Aug 2009
• Concerns about consensus guidelines for QTc interval screening in methadone treatment. 2 Aug 2009
• Concerns about consensus guidelines for QTc interval screening in methadone treatment. 2 Aug 2009
• Concerns about consensus guidelines for QTc interval screening in methadone treatment. 2 Aug 2009
• Concerns about consensus guidelines for QTc interval screening in methadone treatment. 2 Aug 2009
• [Mechanisms of opioid-induced overdose: experimental approach to clinical concerns] Aug 2009
• Injection of medications used in opioid substitution treatment in Australia after the introduction of a mixed partial agonist-antagonist formulation. Aug 2009
• Opioid dependence treatment: options in pharmacotherapy. 30 Jul 2009
• [Opiate replacement therapy in France: assessment of the public policies] 28 Jul 2009
• Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program. 22 Jul 2009
• Sustained attention in patients receiving and abstinent following methadone maintenance treatment for opiate dependence: performance and neuroimaging results. 13 Jul 2009

See a longer list of these articles.

Technical information about 'Methadone'

Definition: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

Chemical name: 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-

Registry Number: 76-99-3

Descriptor UI: D008691

Alternative terms: Methadone; Dolophine; Roxane Brand of Methadone Hydrochloride; Methadone Hydrochloride; Hydrochloride, Methadone; Phenadone; Physeptone; GlaxoSmithKline Brand of Methadone Hydrochloride; Martindale Brand of Methadone Hydrochloride; Phymet; Symoron; Yamanouchi Brand of Methadone Hydrochloride; Metadol; Pharmascience Brand of Methadone Hydrochloride; Metasedin; Esteve Brand of Methadone Hydrochloride; Methaddict; addiCare Brand of Methadone Hydrochloride; Methadose; Rosemont Brand of Methadone Hydrochloride; Mallinckrodt Brand of Methadone Hydrochloride; Methex; Generics Brand of Methadone Hydrochloride; Pinadone; Pinewood Brand of Methadone Hydrochloride; Amidone; Biodone; Biomet Brand of Methadone Hydrochloride;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Antitussive Agents; Narcotics; Analgesics, Opioid;

Tree Number: D02.522.675;

Technical Notes: with disease term, use /rehabil rather than /drug ther