Methylphenidate - Chemistry
Research News and Information

Sunday, November 22, 2009

OROS methylphenidate for the treatment of adults with attention-deficit/hyperactivity disorder.

30 Jul 2009 Attention-deficit/hyperactivity disorder (ADHD) is one of the most common behavioral disorders in childhood. It continues into adulthood in up to 65% of patients. Methylphenidate (MPH) is one of the most commonly used pharmacological treatments for ... Read more...

Juvenile methylphenidate exposure and factors that influence incentive processing.

15 Apr 2009 Methylphenidate (MPH) is one of the few psychotropic agents approved for use in pediatric populations, underscoring the importance of elucidating any long-term consequences following exposure to this agent. Here, we examined the influence of several ... Read more...

Developmental toxicity assessment of d,l-methylphenidate and d-methylphenidate in rats and rabbits.

29 Sep 2008 BACKGROUND: Previous investigations reported no teratogenicity for methylphenidate (MPH). These studies investigated potential teratogenicity of d-MPH and d,l-MPH as commitments to the FDA. METHODS: Rabbits received 15, 50, 150 mg/kg/day (mkd) d-MPH ... Read more...

Latest indexed articles for 'Methylphenidate - Chemistry'

These are the very latest articles for this heading:

• OROS methylphenidate for the treatment of adults with attention-deficit/hyperactivity disorder. 30 Jul 2009
• Juvenile methylphenidate exposure and factors that influence incentive processing. 15 Apr 2009
• Developmental toxicity assessment of d,l-methylphenidate and d-methylphenidate in rats and rabbits. 29 Sep 2008
• Efficacy and safety of extended-release dexmethylphenidate compared with d,l-methylphenidate and placebo in the treatment of children with attention-deficit/hyperactivity disorder: a 12-hour laboratory classroom study. 30 May 2008
• Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis. 13 May 2008
• Methylphenidate and cocaine: the same effects on gene regulation? 23 Oct 2007
• Symptom clusters in patients with newly-diagnosed brain tumors. 29 Sep 2007
• Task demands interact with the single and combined effects of medication and contingencies on children with ADHD. 29 Apr 2007
• Synthetic approaches and bio-distribution studies of [11C]methyl-phenidate. 30 Dec 2006
• A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study. 29 Nov 2006
• Dexmethylphenidate extended-release capsules for the treatment of attention deficit hyperactivity disorder. 29 Nov 2006
• Methylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test. 5 Jul 2006
• Methylphenidate and its isomers: their role in the treatment of attention-deficit hyperactivity disorder using a transdermal delivery system. 30 Dec 2005
• The interaction of methylphenidate and benztropine with the dopamine transporter is different than other substrates and ligands. 30 Jul 2005
• Methylphenidate HCl: therapy for attention deficit hyperactivity disorder. 29 Apr 2005
• Synthesis and pharmacology of ethylphenidate enantiomers: the human transesterification metabolite of methylphenidate and ethanol. 19 Apr 2005
• New methylphenidate formulations for the treatment of attention-deficit/hyperactivity disorder. 30 Dec 2004
• Conformational analysis of methylphenidate: comparison of molecular orbital and molecular mechanics methods. 30 Oct 2004
• A double-blind, placebo-controlled trial of dexmethylphenidate hydrochloride and d,l-threo-methylphenidate hydrochloride in children with attention-deficit/hyperactivity disorder. 30 Oct 2004
• Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. 11 Apr 2004

See a longer list of these articles.

Technical information about 'Methylphenidate'

Definition: A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE.

Chemical name: 2-Piperidineacetic acid, alpha-phenyl-, methyl ester

Registry Number: 113-45-1

Descriptor UI: D008774

Alternative terms: Methylphenidate; Dexmethylphenidate; Dexmethylphenidate Hydrochloride; Hydrochloride, Dexmethylphenidate; Focalin; Novartis Pharmaceutical Brand of Dexmethylphenidate Hydrochloride; Metadate; Equasym; Celltech Brand of Methylphenidate Hydrochloride; Methylphenidate Hydrochloride; Hydrochloride, Methylphenidate; Phenidylate; Ritalin; Novartis Brand 1 of Methylphenidate Hydrochloride; Ritaline; Cephalon Brand of Methylphenidate Hydrochloride; Ritalin-SR; Ritalin SR; Novartis Brand 2 of Methylphenidate Hydrochloride; Tsentedrin; Centedrin; Daytrana; Methylin; Mallinckrodt Brand of Methylphenidate Hydrochloride;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Dopamine Uptake Inhibitors; Central Nervous System Stimulants;

Tree Number: D02.241.223.601.600; D03.383.621.460;

Online Note: use METHYLPHENIDATE to search PHENIDYLATE 1978-94

History Note: PHENIDYLATE was see METHYLPHENIDATE 1978-94